Publication

Quenching spin diffusion in selective measurements of transient overhauser effects in nuclear magnetic resonance. Applications to oligonucleotides

Geoffrey Bodenhausen
1994
Journal Articles

Abstract

In high-resoln. NMR, the transfer of longitudinal magnetization from one spin to another (A -> X) under the effect of cross relaxation NOE is often complicated by spin-diffusion pathways through other spins K in the vicinity (e.g., A -> K -> X). It is shown how these undesirable pathways can be quenched by manipulating the magnetization of the two sites A and X with doubly selective inversion pulses. The methods are illustrated by applications to Overhauser effects in the palindromic DNA d(CGCGAATTCGCG)2, which forms a B-type double helix. [on SciFinder (R)]

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https://infoscience.epfl.ch/entities/publication/340bc558-9c91-446e-aff3-4ee8e9dbc9f2

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Geoffrey Bodenhausen
1994
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/340bc558-9c91-446e-aff3-4ee8e9dbc9f2

About this result

Related concepts (26)

Nuclear Overhauser effect

The nuclear Overhauser effect (NOE) is the transfer of nuclear spin polarization from one population of spin-active nuclei (e.g. 1H, 13C, 15N etc.) to another via cross-relaxation. A phenomenological definition of the NOE in nuclear magnetic resonance spectroscopy (NMR) is the change in the integrated intensity (positive or negative) of one NMR resonance that occurs when another is saturated by irradiation with an RF field. The change in resonance intensity of a nucleus is a consequence of the nucleus being close in space to those directly affected by the RF perturbation.

Nuclear magnetic resonance spectroscopy

Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a spectroscopic technique to observe local magnetic fields around atomic nuclei. This spectroscopy is based on the measurement of absorption of electromagnetic radiations in the radio frequency region from roughly 4 to 900 MHz. Absorption of radio waves in the presence of magnetic field is accompanied by a special type of nuclear transition, and for this reason, such type of spectroscopy is known as Nuclear Magnetic Resonance Spectroscopy.

Nuclear magnetic resonance

Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus. This process occurs near resonance, when the oscillation frequency matches the intrinsic frequency of the nuclei, which depends on the strength of the static magnetic field, the chemical environment, and the magnetic properties of the isotope involved; in practical applications with static magnetic fields up to ca.

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Quenching spin diffusion in selective measurements of transient overhauser effects in nuclear magnetic resonance. Applications to oligonucleotides

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