Publication

Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones

Jieping Zhu, Ruben Omar Torres Ochoa
2020
Journal Articles

Abstract

In the presence of a catalytic amount of Pd(OAc)(2) and XantPhos, the three-component reaction of ynones, imines, and aryl iodides affords fully substituted alkylidene-furan-3(2H)-ones via a sequence of the Mannich reaction followed by chemo- and regioselective oxypalladation and reductive elimination. One carbon-oxygen and two carbon-carbon bonds are generated to afford the heterocycle in good to excellent yield.

Official source

https://infoscience.epfl.ch/entities/publication/32612200-ec5f-4854-9e98-a64d3d153425

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Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones

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