Publication

Palladium-Catalyzed Through-Space C(sp3)-H and C(sp2)-H Bond Activation by 1,4-Palladium Migration: Efficient Synthesis of [3,4]- Fused Oxindoles

Jieping Zhu, Qian Wang, Ala Bunescu
2013
Journal Articles

Abstract

Palladium two step: Linear anilides were converted into the title compounds in good to excellent yields through a palladium-catalyzed domino carbopalladation/1,4-palladium shift sequence. The C(sp3)-H activation involves a seven-membered palladacycle, and is chemoselective in the presence of competitive C(sp2)H bonds. DMA=N,N-dimethylacetamide, OPiv=pivalate.

Official source

https://infoscience.epfl.ch/entities/publication/31c9f585-38ef-466e-b17a-6c709195190e

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Palladium-Catalyzed Through-Space C(sp3)-H and C(sp2)-H Bond Activation by 1,4-Palladium Migration: Efficient Synthesis of [3,4]- Fused Oxindoles

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