Publication

Dissecting the epigenetic regulation of human brain organoid development in single cells

Fides Zenk
2024

Abstract

We present a developmental atlas that offers insight into sequential epigenetic changes underlying early human brain development modeled in organoids, which reconstructs the differentiation trajectories of all major CNS regions. It shows that epigenetic regulation via the installation of activating histone marks precedes activation of groups of neuronal genes.

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Dissecting the epigenetic regulation of human brain organoid development in single cells

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