Publication

Determination of internuclear distances by suppressing spin diffusion in rotating-frame Overhauser measurements

Geoffrey Bodenhausen
1999
Journal Articles

Abstract

In off-resonance rotating-frame Overhauser spectroscopy (OFF-ROESY), spin-diffusion effects can be suppressed in selected spectral regions by doubly-selective inversion of the magnetization in the middle of the cross-relaxation interval. The resulting quenching of undesirable indirect external trouble in off-resonance rotating-frame Overhauser effect spectroscopy (QUIET-OFF-ROESY) expt. yields direct information about cross-relaxation rates between selected pairs of spins, as if the two-spin subsystems were isolated from their surroundings. When the cross-relaxation rates of a macromol. are obsd. under spin-locked conditions with an effective field tilted by an angle 35.3 Deg < q < 90 Deg with respect to the z-axis of the rotating frame, the intensity of cross-peaks may be increased if contributions due to spin diffusion are suppressed. Applications to a desoxyribonucleic acid dodecamer demonstrate that the precision of the detn. of internuclear distances can be significantly improved if spin diffusion is quenched. [on SciFinder (R)]

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https://infoscience.epfl.ch/entities/publication/3133146a-aed4-4721-9418-0a1645b15f7d

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Geoffrey Bodenhausen
1999
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/3133146a-aed4-4721-9418-0a1645b15f7d

About this result

Related concepts (31)

Two-dimensional nuclear magnetic resonance spectroscopy

Two-dimensional nuclear magnetic resonance spectroscopy (2D NMR) is a set of nuclear magnetic resonance spectroscopy (NMR) methods which give data plotted in a space defined by two frequency axes rather than one. Types of 2D NMR include correlation spectroscopy (COSY), J-spectroscopy, exchange spectroscopy (EXSY), and nuclear Overhauser effect spectroscopy (NOESY). Two-dimensional NMR spectra provide more information about a molecule than one-dimensional NMR spectra and are especially useful in determining the structure of a molecule, particularly for molecules that are too complicated to work with using one-dimensional NMR.

Nuclear Overhauser effect

The nuclear Overhauser effect (NOE) is the transfer of nuclear spin polarization from one population of spin-active nuclei (e.g. 1H, 13C, 15N etc.) to another via cross-relaxation. A phenomenological definition of the NOE in nuclear magnetic resonance spectroscopy (NMR) is the change in the integrated intensity (positive or negative) of one NMR resonance that occurs when another is saturated by irradiation with an RF field. The change in resonance intensity of a nucleus is a consequence of the nucleus being close in space to those directly affected by the RF perturbation.

Rotating reference frame

A rotating frame of reference is a special case of a non-inertial reference frame that is rotating relative to an inertial reference frame. An everyday example of a rotating reference frame is the surface of the Earth. (This article considers only frames rotating about a fixed axis. For more general rotations, see Euler angles.) Fictitious force All non-inertial reference frames exhibit fictitious forces; rotating reference frames are characterized by three: the centrifugal force, the Coriolis force, and, for non-uniformly rotating reference frames, the Euler force.

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Determination of internuclear distances by suppressing spin diffusion in rotating-frame Overhauser measurements

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