Publication

High resolution SPAD array-based diffuse optical tomography facilitates longitudinal monitoring of osteosarcoma growth in mice

2026

Abstract

We present a free-space time-domain diffuse optical tomography (TD-DOT) system that integrates SPAD array detection with geometric calibration for accurate, non-invasive tumor imaging. By combining structured-light surface extraction with calibration of source positions and detector responses, the system enables precise modeling of photon transport in air. Phantom studies demonstrate improved reconstruction accuracy across diverse shapes, while longitudinal in vivo imaging of mice with dorsal tumor reveals consistent changes in tumor volume and optical properties. These results demonstrate that our system enables high-quality, quantitative monitoring of tumor progression, underscoring its utility in preclinical research.

Official source

https://infoscience.epfl.ch/entities/publication/30dcca7a-ac1a-4a4b-9f82-4e2af40a67dc

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

2026

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/30dcca7a-ac1a-4a4b-9f82-4e2af40a67dc

About this result

Related concepts (23)

Brain tumor

A brain tumor occurs when abnormal cells form within the brain. There are two main types of tumors: malignant tumors and benign (non-cancerous) tumors. These can be further classified as primary tumors, which start within the brain, and secondary tumors, which most commonly have spread from tumors located outside the brain, known as brain metastasis tumors. All types of brain tumors may produce symptoms that vary depending on the size of the tumor and the part of the brain that is involved.

Neuroendocrine tumor

Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. They most commonly occur in the intestine, where they are often called carcinoid tumors, but they are also found in the pancreas, lung, and the rest of the body. Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common features, including a similar histological appearance, having special secretory granules, and often producing biogenic amines and polypeptide hormones.

Benign tumor

A benign tumor is a mass of cells (tumor) that does not invade neighboring tissue or metastasize (spread throughout the body). Compared to malignant (cancerous) tumors, benign tumors generally have a slower growth rate. Benign tumors have relatively well differentiated cells. They are often surrounded by an outer surface (fibrous sheath of connective tissue) or stay contained within the epithelium. Common examples of benign tumors include moles and uterine fibroids. Some forms of benign tumors may be harmful to health.

Related publications (2)

High resolution SPAD array-based diffuse optical tomography facilitates longitudinal monitoring of osteosarcoma growth in mice

Chat with Graph Search

A hybrid optimized framework with energy shape prior segmentation for brain tumor detection in MRI images

Numerical approximation of phase field models for tumor growth