Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides

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Despite significant advances in the treatment of cardiovascular diseases, antiplatelet therapies are still associated with a high risk of hemorrhage. In order to develop new drugs, methods to measure platelet function must be adapted for the high-throughpu ...

Gene delivery using vector or viral-based methods is often limited by technical and safety barriers. A promising alternative that circumvents these shortcomings is the direct delivery of proteins into cells. Here we introduce a non-viral, ligand-mediated p ...

Atroxlysin-III (Atr-III) was purified from the venom of Bothrops atrox. This 56-kDa protein bears N-linked glycoconjugates and is a P-III hemorrhagic metalloproteinase. Its cDNA-deduced amino acid sequence reveals a multidomain structure including a propro ...

Despite significant advances in the treatment of thrombogenic diseases, antiplatelet therapies are still associated with a high bleeding risk. Consequently, potential benefits of preventing thromboembolic events by pharmacological agents need to be balance ...

Peptides represent a promising molecular class for drug development. They combine several strengths of small molecules (e.g. efficient tissue diffusion, low immunogenicity and access to chemical synthesis) and key properties of biologics such as monoclonal ...

Two dicopper (II) complexes of general formula CuLX2 {L = 2, 5-diphenyl-3, 4(2-pyridyl) cyclopenta-2, 4-dien-1-one, X = Cl (1) or Br (2)} have been synthesized and characterized by elemental analysis, IR, UV-Vis spectroscopic methods. The crystal stru ...

Annulated pyridones are an importantscaffold found in many biologically active compounds. ANi(0)-catalyzed C−H functionalization of 2- and 4-pyridones is disclosed, providing access to annulatedpyridones via enantioselective intramolecular olefin hydro-ary ...

The addition of a metastable-state photoacid to solutions containing metal–ligand assemblies renders the systems light responsive. Upon irradiation, proton transfer from the photoacid to the ligand is observed, resulting in disassembly of the metallasupram ...

Peptides and small protein scaffolds are gaining increasing interest as therapeutics. Similarly to full-length antibodies, they can bind a target with a high binding affinity and specificity while remaining small enough to diffuse into tissues. However, de ...

Designing compounds that bind to the acidic patch of the nucleosome core particle (NCP) is an emerging therapeutic approach that can inhibit the binding of key chromatin factors. Pretreatment of human ovarian carcinoma, A2780, cells with RAPTA-T, an antime ...

Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides

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An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

A ligand-based system for receptor-specific delivery of proteins

Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergon) Induces Glycoprotein VI Shedding and Impairs Platelet Function

From Patients to Platelets and Back Again: Pharmacological Approaches to Glycoprotein VI, a Thrilling Antithrombotic Target with Minor Bleeding Risks

Development of cyclic peptide inhibitors of coagulation factor XII and matrix metalloproteinase 2

Double bridged mu(2)-Halide Cu (II) complexes for the electrocatalytic reduction of CO2

Nickel-Catalyzed Enantioselective Pyridone C-H Functionalizations Enabled by a Bulky N-Heterocyclic Carbene Ligand

Reversible disassembly of metallasupramolecular structures mediated by a metastable-state photoacid

Non-covalent albumin-binding ligands for extending the circulating half-life of small biotherapeutics

Crosslinking Allosteric Sites on the Nucleosome Core Particle