Publication

Star-shaped fluorescent polypeptides

2001
Journal Articles

Abstract

Two series of novel, four-arm, star-shaped polypeptides were prepared via the ring-opening polymerization of γ-benzyl-L-glutamate N-carboxyanhydride and ε-benzyloxycarbonyl-L-lysine N-carboxyanhydride with a tetra-amino-substituted perylene fluorophore as the initiator. The removal of the α-amino acid side-chain-protecting groups resulted in unprecedented water-soluble, perylene-functionalized, star-shaped polypeptides that showed strong fluorescence in aqueous solution. One of the features that distinguished these water-soluble star polypeptides from most other star polymers was that the conformation of the arms could be reversibly changed from a random coil into an α helix by variations in the pH of the aqueous solution. These star polypeptides might be of interest for the development of novel fluorescent probes or as traceable, stimuli-sensitive molecular containers. © 2001 John Wiley & Sons, Inc.

Official source

https://infoscience.epfl.ch/entities/publication/30a864af-b51c-4d9d-8762-ced771d76ed4

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2001
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/30a864af-b51c-4d9d-8762-ced771d76ed4

About this result

Related concepts (22)

Ring-opening polymerization

In polymer chemistry, ring-opening polymerization (ROP) is a form of chain-growth polymerization, in which the terminus of a polymer chain attacks cyclic monomers to form a longer polymer (see figure). The reactive center can be radical, anionic or cationic. Some cyclic monomers such as norbornene or cyclooctadiene can be polymerized to high molecular weight polymers by using metal catalysts. ROP is a versatile method for the synthesis of biopolymers. Ring-opening of cyclic monomers is often driven by the relief of bond-angle strain.

Polymerization

In polymer chemistry, polymerization (American English), or polymerisation (British English), is a process of reacting monomer molecules together in a chemical reaction to form polymer chains or three-dimensional networks. There are many forms of polymerization and different systems exist to categorize them. In chemical compounds, polymerization can occur via a variety of reaction mechanisms that vary in complexity due to the functional groups present in the reactants and their inherent steric effects.

Living polymerization

In polymer chemistry, living polymerization is a form of chain growth polymerization where the ability of a growing polymer chain to terminate has been removed. This can be accomplished in a variety of ways. Chain termination and chain transfer reactions are absent and the rate of chain initiation is also much larger than the rate of chain propagation. The result is that the polymer chains grow at a more constant rate than seen in traditional chain polymerization and their lengths remain very similar (i.e.

Related publications (2)

Star-shaped fluorescent polypeptides

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