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The present paper investigates the prospects of process integration of the biogenic production of crude synthetic natural gas (SNG) and its upgrade to grid quality. At the example of a separation by means of a membrane cascade, a holistic design approach targeting the overall process performances is presented. Compared to a design obtained from an isolated approach, it is shown that a considerable reduction of the size and cost of the separation system is possible if a tight process integration is considered in the system design.