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Pharmacokinetics of tetra(m-hydroxyphenyl)chlorin in human plasma and individualized light dosimetry in photodynamic therapy

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Lateral Intermolecular Electronic Interactions of Diketopyrrolopyrrole D−π–A Solar Dye Sensitizers Adsorbed on Mesoporous Alumina

Jacques-Edouard Moser, Ulf Anders Hagfeldt, Heewon Bahng

The development of push−pull organic dyes utilizing the donor−(π-conjugated bridge)−acceptor (D−π−A) motif has induced a paradigm shift in the design of efficient nanocrystalline dye-sensitized solar cells (DSSCs), offering control over the aesthetic prope ...

2018

Chemistry and Analysis of Nanoparticle-Modified Living Cells

Tanja Thomsen

Conventional therapeutics are often limited by their targeting ability, resulting in harmful and potential fatal side-effects for the patients. Recently, new strategies have been developed to improve target specificity of drugs in order to generate more ef ...

EPFL2020

Ultrafast X-ray Spectroscopy of Heme Proteins

Dominik Kinschel

With the advent of X-ray free-electron lasers (XFELs) time-resolved X-ray spectroscopic techniques have advanced to the femtosecond regime. These are element selective techniques which offer unique insight into the electronic and chemical environment and d ...

EPFL2020

A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy

Kai Johnsson, Lu Wang, Lin Xue

It is difficult to develop suitable fluorescent probes for live-cell nanoscopy, but a general strategy is now reported that can transform regular fluorophores into fluorogenic probes with excellent cell permeability and low unspecific background signals. U ...

NATURE PUBLISHING GROUP2020

Applications of a reconfigurable SPAD line imager

Edoardo Charbon, Claudio Bruschini, Samuel Burri

Single-photon avalanche diodes (SPADs) fabricated in standard CMOS processes enable cost-effective volume production of sensors capable of time-stamping individual photons with high accuracy. This capability makes the sensors ideally suited for application ...

2018

Distributed optical fiber sensing based on frequency-scanned phase-sensitive optical time-domain reflectometry

Li Zhang

Unlike traditional sensing schemes which rely on discrete point sensors that perform measurements at predetermined positions, distributed optical fiber sensing is a general technique that enables to continuously gather information (typically temperature an ...

EPFL2020

Methods of derivation and/or propagation of epithelial cells

Yann Barrandon, Andrea Zaffalon

The present invention relates to methods of derivation and/or propagation of epithelial cells from tissue comprising culturing said tissue in media containing an effective amount of a proprotein convertase inhibitor for a period of time allowing the deriva ...

2018

Precision Positioning of Microrobots for Multi-Object Spectrographs

Luzius Gregor Kronig

How does one study the evolution of the Milky Way, or the expansion of the Universe, or explore the mysteries of Dark energy? To investigate these complex topics, astronomers require data, and a great deal of it, in the form of the spectra of stars, galaxi ...

EPFL2020

Priority coordination of fiber positioners in multi-objects spectrographs

Denis Gillet, Jean-Paul Richard Kneib, Mohamed Bouri, Laleh Makarem

Projects such as "The Dark Energy Spectroscopic Instrument" (DESI) [1] or "The Multi Object Optical and Near-infrared Spectrograph" (MOONS) [5] are developing spectrographs, composed of more than thousand of optical fibers in a confined hexagonal focal pla ...

SPIE-INT SOC OPTICAL ENGINEERING2018

Modes interplay controls the second harmonic generation dynamics of plasmonic nanostructures

Olivier Martin, Andrei Kiselev, Gabriel David Bernasconi

A large amount of experimental and theoretical works deals with the second harmonic generation from different plasmonic geometries. Since they often consider relatively long optical pulses, many of these studies are focused on the investigation of a quasi- ...

SPIE2020

Modulation of the endogenous production of protoporphyrin IX in a yeast - based model organism

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli

The main aim of this study was to assess conditions at which simple yeast-based model organism produces maximal levels of protoporphyrin IX (PpIX) after an exogenous administration of its precursor, 5-aminolevulinic acid (ALA), and the ferrous-ion chelator ...

Spie-Int Soc Optical Engineering2017

Coherent generation of symmetry-forbidden phonons by light-induced electron-phonon interactions in magnetite

Oleg Yazyev, Fabrizio Carbone, Frank van Mourik, Edoardo Baldini, Christopher Alexander Arrell, Andreas Helmut Christian Mann, Simone Borroni

Symmetry breaking across phase transitions often causes changes in selection rules and emergence of optical modes which can be detected via spectroscopic techniques or generated coherently in pump-probe experiments. In second-order or weakly first-order tr ...

Amer Physical Soc2017

Neutron spectroscopy in the layered quantum magnet SrCu₂(BO₃)₂ and in transition metal phosphorus trisulfides (MPS₃)

Diane Virginie Marie Lançon

Collective magnetic excitations are a fascinating aspect of condensed matter physics, where neutron scattering can provide valuable insight into the magnetic properties of physical realisations of model systems. This thesis focuses on the excitation spectr ...

EPFL2017

In Silico Brain Imaging Physically-plausible Methods for Visualizing Neocortical Microcircuitry

Marwan Muhammad Ahmed Abdellah

The recent years have witnessed growing interest in the power of scientific visualization for simulation-based neuroscience. The research presented in this thesis develops methods to generate physically-realistic visualizations of neocortical models recons ...

EPFL2017

Protein Bioconjugation to Carbon Nanotubes for Near-Infrared Sensing

Vitalijs Zubkovs

Single-walled carbon nanotubes (SWCNTs) are a promising material for electrochemical and optical biosensing applications. Their small dimensions, large surface area, indefinite photostability, and remarkable electronic properties make SWCNTs an ideal trans ...

EPFL2019