Publication

Disruption of notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice

2012
Journal Articles

Abstract

Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs).

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2012
Journal Articles

Abstract

Official source

Related concepts (16)

Angiogenesis

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis. Angiogenesis continues the growth of the vasculature mainly by processes of sprouting and splitting, but processes such as coalescent angiogenesis, vessel elongation and vessel cooption also play a role. Vasculogenesis is the embryonic formation of endothelial cells from mesoderm cell precursors, and from neovascularization, although discussions are not always precise (especially in older texts).

Neovascularization

Neovascularization is the natural formation of new blood vessels (neo- + vascular + -ization), usually in the form of functional microvascular networks, capable of perfusion by red blood cells, that form to serve as collateral circulation in response to local poor perfusion or ischemia. Growth factors that inhibit neovascularization include those that affect endothelial cell division and differentiation.

Clinical trial

Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought.

Related publications (3)

Disruption of notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice

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Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

Angiogenesis inhibition for the improvement of photodynamic therapy: The revival of a promising idea

Vascular regrowth following photodynamic therapy in the chicken embryo chorioallantoic membrane