Publication

Performance of Free-Running Cardiac and Respiratory Motion-Resolved Whole-Heart 5D MRI in Congenital Heart Disease Patients Using a Gadolinium Enhanced Fast-Interrupted Steady-State Sequence

2026

Abstract

Background: The performance of 5D imaging in CHD has been previously demonstrated using ferumoxytol rather than gadolinium. Purpose: To evaluate the performance of gadolinium enhanced 5D MRI relative to 2D and 3D MRI in CHD patients. Study Type: Retrospective. Subjects: 45 consecutive CHD patients referred for clinically indicated MRI who underwent 2D, 3D, and 5D MRI. Field Strength/Sequence: 2D bSSFP CINE, 3D bSSFP, and 5D FISS at 1.5 T. Assessment: Scan time (2D, 3D, and 5D), left and right ventricular (LV, RV) end diastolic and end systolic volumes (LVEDV, RVEDV, LVESV, and RVESV, respectively), ejection fraction (LVEF, RVEF) for 2D versus 5D, and image quality on a 4-point Likert scale (3D vs. 5D). Statistical Tests: Paired comparisons were made using a paired t-test or Wilcoxon signed rank test. Agreement between measurements was evaluated with Bland–Altman analysis including the bias and 95% limits of agreement. Results: Scan time for 5D (6:18 [0]) was significantly shorter than 2D (7:16 [4:39]) and 3D (6:55 [1:30]) MRI. 5D measurements were strongly correlated with 2D measurements of LVEDV (R2 = 0.94), LVESV (R2 = 0.83), LVEF (R2 = 0.51), (R2 = 0.85), RVESV (R2 = 0.80), and RVEF (R2 = 0.66) but with significant biases. Sharpness of the coronary arteries were significantly higher for 3D (RCA: 36.8% ± 10.2%, LAD: 40.5% ± 10.5%) than 5D (RCA: 24.3% ± 7.5%, LAD: 31.7% ± 8.7%), but longer vessel segments were visible using 5D (LAD: 6.9 ± 2.5) than 3D (LAD: 5.3 ± 2.9 mm) acquisitions. The grades for 5D (R1: 3 [1], R2: 2.5 [0.5], R3: 3 [0.6]) were significantly higher than 3D (R1: 3 [1], R2: 2.5 [1], R3: 2 [1]). Data Conclusion: Gadolinium-enhanced 5D MRI may provide an efficient and simplified acquisition for CHD patients, with multiple quantitative parameters from 5D being not significantly different from those from reference standard 2D and 3D MRI. Evidence Level: 4. Stage of Technical Efficacy: 1.

Official source

https://infoscience.epfl.ch/entities/publication/2e3d26e5-e8ee-45c7-8a77-72b9198ca627

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2026

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/2e3d26e5-e8ee-45c7-8a77-72b9198ca627

About this result

Related concepts (32)

Paired difference test

In statistics, a paired difference test is a type of location test that is used when comparing two sets of paired measurements to assess whether their population means differ. A paired difference test uses additional information about the sample that is not present in an ordinary unpaired testing situation, either to increase the statistical power, or to reduce the effects of confounders.

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The sign test is a statistical method to test for consistent differences between pairs of observations, such as the weight of subjects before and after treatment. Given pairs of observations (such as weight pre- and post-treatment) for each subject, the sign test determines if one member of the pair (such as pre-treatment) tends to be greater than (or less than) the other member of the pair (such as post-treatment). The paired observations may be designated x and y.

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Performance of Free-Running Cardiac and Respiratory Motion-Resolved Whole-Heart 5D MRI in Congenital Heart Disease Patients Using a Gadolinium Enhanced Fast-Interrupted Steady-State Sequence

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