Publications related to In vivo cyclic loading as a potent stimulatory signal for bone formation inside tissue engineering scaffolds

Related publications (34)

Intake of Neutral Core Human Milk Oligosaccharides (hmos) During Early Life Improves Long-term Bone Quality

Infancy is a key period for bone growth, determining bone strength later in life. Studies have provided early insights into the role that human milk oligosaccharides (HMOs) may play in growth, potentially through their effects on the microbiome. However, f ...

ELSEVIER SCIENCE INC2025

Deciphering tensile fatigue behavior of UHPFRC using magnetoscopy, DIC and acoustic emission

Eugen Brühwiler, Alain Nussbaumer, Jian Zhan

To explore the governing mechanism underlying the tensile fatigue behavior of Ultra-high Performance Fiber Reinforced Cementitious Composites (UHPFRC), this study tested eight specimens using four advanced non-destructive measurement techniques. First, mag ...

2025

Synergetic Support of Cartilage Homeostasis via Coupled Thermal-Hydrostatic Pressure Stimuli

Yanheng Guo

Cartilage homeostasis, crucial for musculoskeletal function, is orchestrated by interconnected biophysical cues. In healthy cartilage, repetitive compressive loading not only elicits a range of mechanical stimuli but also induces a gradual transient temper ...

EPFL2024

Enhancing Chondrocyte Biosynthetic Activities: Harnessing the Power of Loading-Induced Evolved Temperature

Theofanis Stampoultzis

Chondrocytes within articular cartilage possess the capacity to perceive and react to signals generated by the typical load-bearing actions of daily life, such as walking or running. Articular cartilage is predominantly oriented toward compression-based fu ...

EPFL2024

Can lateral tenodesis improve the rotational stability of the ACL reconstruction? A finite element analysis

Dimitar Yuriev Stanev

One of the most common knee injuries is the Anterior Cruciate Ligament (ACL) rupture with severe implications on knee stability. The usual treatment is the ACL Reconstruction (ACLR) surgery where the surgeon replaces the torn ligament with a graft in an ef ...

Public Library Science2024

Improved Material Formulations for Thick Adhesive Joints in Wind Turbine Blades

Jialiang Fan

Wind turbine rotor blades are usually fabricated using composite materials and epoxy adhesive to bond the elements together. Due to their large size, the thickness of the adhesive layer varies from 1 to up to 30 mm depending on the position. The failure of ...

EPFL2024

Uniaxial Cyclic and Tensile Tests on Structural Metallic Materials

Dimitrios Lignos, Albano António De Abreu E Presa De Castro E Sousa, Selimcan Ozden

Experimental data is imperative to characterize the behavior of materials used in structural analysis models. The aim of this data paper is to establish a database of material-scale uniaxial experiments, primarily conducted at EPFL, to assist with simulati ...

ASCE-AMER SOC CIVIL ENGINEERS2023

Diverse parameters of ambulatory knee moments differ with medial knee osteoarthritis severity and are combinable into a severity index

Julien Favre, Brigitte Jolles-Haeberli

Objective: To characterize ambulatory knee moments with respect to medial knee osteoarthritis (OA) severity comprehensively and to assess the possibility of developing a severity index combining knee moment parameters. ...

FRONTIERS MEDIA SA2023

Modeling of solids particle diversion to promote uniform growth of multiple hydraulic fractures

Guanyi Lu

Solid particulate additives are sometimes used to promote the uniform growth of multiple hydraulic fractures in horizontal oil and gas wells. The principle is that solid particulates block, accumulate, and form larger porous plugging zones preferentially a ...

ELSEVIER2023

Overcorrected Implants for Total Shoulder Arthroplasty

Yasmine Boulanaache

Glenohumeral osteoarthritis is a degenerative shoulder joint disease, which causes the breakdown of articular cartilage and bone. People affected by this disease suffer from severe pain and eventually reduced mobility and poor life quality. This disease is ...

EPFL2021

Influence of the sintering atmosphere on the physico-chemical properties and the osteoclastic resorption of β-tricalcium phosphate cylinders

Paul Bowen, Duncan Thomas Lindsay Alexander, Gabrielle Anne Laguisma Sblendorio

One of the most widely used materials for bone graft substitution is β-Tricalcium phosphate (β-TCP;β- Ca3(PO4)2). beta-TCP is typically produced by sintering in air or vacuum. During this process, evaporation of phosphorus ...

Elsevier Sci Ltd2023

Microtensile failure mechanisms in lamellar bone: Influence of fibrillar orientation, specimen size and hydration

Johann Michler, Daniele Casari

A mechanistic understanding of bone fracture is indispensable for developing improved fracture risk assessment in clinics. Since bone is a hierarchically structured material, gaining such knowledge requires analysis at multiple length scales. Here, the ten ...

ELSEVIER SCI LTD2021

Controlling the Microstructure and Composition of 3D Printed Soft Load-Bearing Hydrogels

Matteo Hirsch

Hydrogels are among the first materials expressly designed for their use in biomedicine. However, state-of-the-art applications of hydrogels are severely limited because they are typically either too soft or too brittle such that they cannot bear significa ...

EPFL2023

Atomistic simulation and electron microscopy to characterize grain boundaries in doped beta-tricalcium phosphate ceramics

Gabrielle Anne Laguisma Sblendorio

The limitations and potential complications correlated with autogenous bone grafts have raised interest in the development of synthetic bone graft substitutes. ß-tricalcium phosphate (ß-TCP) is one of the most promising materials for synthetic bone graft s ...

EPFL2021

SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation

Johan Auwerx, Dongryeol Ryu, Lilia Noriega Lopez

SIRT7 is a NAD(+)-dependent deacetylase that controls important aspects of metabolism, cancer, and bone formation. However, the molecular targets and functions of SIRT7 in the kidney are currently unknown. In silico analysis of kidney transcripts of the BX ...

2021

Multi-scale modeling of aggregate interlock phenomena in concrete

Mohit Pundir

In concrete structures, opened cracks contribute significantly to the transfer of shear and normal stresses through the contact forces occurring between fractured surfaces. Such contact forces are due to protruding asperities, engaged by interlocking and f ...

EPFL2021

Sub-trabecular strain evolution in human trabecular bone

Goran Lovric, Alessandra Patera

To comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distrib ...

NATURE RESEARCH2020

Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment

Matthias Lütolf, Olaia Maria Naveiras Torres-Quiroga, Aline Roch, Philipp Sebastian Lienemann, Stéphanie Elisabeth Metzger, Queralt Vallmajó Martín

The treatment of bone defects with recombinant bone morphogenetic protein-2 (BMP-2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low-dose BMP-2-based bone regeneration by mob ...

WILEY2020

Synthesis and characterizations of biocompatible polymers and carbon nanotubes-based hybrids for biomedical applications

Lakshmi Devi Chakkarapani

The outstanding physico-chemical properties of carbon nanotubes (CNTs) applied to rectify the problems in bone tissue engineering through enhancing cell proliferation, adhesion and viability, which lead to the improvement in bone replacement, growth and he ...

2020

Age- and sex-specific normative values of bone mineral density in the adult glenoid

Dominique Pioletti, Alexandre Terrier, Alain Farron, Philippe Büchler, Patrick Goetti, Frédéric Vauclair

The objective of this study was to determine the normative bone mineral density (BMD) of cortical and trabecular bone regions in the adult glenoid and its dependence on the subject's age and sex. We analyzed computed tomography (CT) scans of 441 shoulders ...

WILEY2022