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Publication

Aza-Annulation Strategies in Alkaloid Total Synthesis

Karl Gademann
2008
Journal Articles

Abstract

This review highlights the synthesis of nitrogen-containing natural products via aza-annulation. Strategic, tactical, and methodological perspectives are discussed, including recent developments such as metal- or organocatalyzed reactions, oxidative or reductive cyclizations, biomimetic processes, cascade reactions, and cycloadditions. Such key steps are presented in the context of the total syntheses of tropinone, batzelladine, lyconadin, FR901483, strychnofoline, discorhabdin, necatarone, aspidophytine, dibromophakellstatin, anachelin, the acridones, alkaloid GB13, cephalotaxine, strychnine, setoclavine, porantherine, vallesamine, nitraramine, cylindricine, the daphniphyllines, symbioimine, alstonerine, tangutorine and flustramine.

Official source

https://infoscience.epfl.ch/entities/publication/2ca2dc2e-9a70-4b8b-a425-9a2d38a1de7e

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Karl Gademann
2008
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/2ca2dc2e-9a70-4b8b-a425-9a2d38a1de7e

About this result

Related concepts (25)

Total synthesis

Total synthesis is the complete chemical synthesis of a complex molecule, often a natural product, from simple, commercially-available precursors. It usually refers to a process not involving the aid of biological processes, which distinguishes it from semisynthesis. Syntheses may sometimes conclude at a precursor with further known synthetic pathways to a target molecule, in which case it is known as a formal synthesis. Total synthesis target molecules can be natural products, medicinally-important active ingredients, known intermediates, or molecules of theoretical interest.

Strategy

Strategy (from Greek στρατηγία stratēgia, "art of troop leader; office of general, command, generalship") is a general plan to achieve one or more long-term or overall goals under conditions of uncertainty. In the sense of the "art of the general", which included several subsets of skills including military tactics, siegecraft, logistics etc., the term came into use in the 6th century C.E. in Eastern Roman terminology, and was translated into Western vernacular languages only in the 18th century.

Chemical synthesis

In chemistry, chemical synthesis (chemical combination) is the artificial execution of chemical reactions to obtain one or several products. This occurs by physical and chemical manipulations usually involving one or more reactions. In modern laboratory uses, the process is reproducible and reliable. A chemical synthesis involves one or more compounds (known as reagents or reactants) that will experience a transformation when subjected to certain conditions. Various reaction types can be applied to formulate a desired product.

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Aza-Annulation Strategies in Alkaloid Total Synthesis

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