KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

KRAB Zinc Finger Proteins (KZFPs) are a large mammalian transcription factor family, which has mainly been studied for its ability to silence and tame transposable elements (TEs) - a controlling effect brought by the ubiquitous KZFP protein partner, TRIM28 ...

Chromatin-modifying enzymes target distinct residues within histones to finetune gene expression profiles. SIRT7 is an NAD+-dependent deacylase often deregulated in cancer, which deacetylates either H3 lysine 36 (H3K36) or H3K18 with high specificity withi ...

The control of eukaryotic gene expression is intimately connected to highly dynamic chromatin structures. Gene regulation relies on activator and repressor transcription factors (TFs) that induce local chromatin opening and closing. However, it is unclear ...

Terrestrial particle accelerators collide charged particles, then watch the trajectory of outgoing debris - but they cannot manipulate dark matter. Fortunately, dark matter is the main component of galaxy clusters, which are continuously pulled together by ...

Context. The intracluster medium (ICM) is the low-density diffuse gas that fills the space between galaxies within galaxy clusters. It is primarily composed of magnetized plasma, which reaches virial temperatures of up to 10(8) K, probably due to mergers o ...

We use 0.1 '' observations from the Atacama Large Millimeter Array (ALMA), Hubble Space Telescope (HST), and JWST to study young massive clusters (YMCs) in their embedded "infant" phase across the central starburst ring in NGC 3351. Our new ALMA data revea ...

Cluster-scale strong lensing is a powerful tool for exploring the properties of dark matter and constraining cosmological models. However, due to the complex parameter space, pixelized strong lens modelling in galaxy clusters is computationally expensive, ...

Context. The Euclid mission of the European Space Agency will perform a survey of weak lensing cosmic shear and galaxy clustering in order to constrain cosmological models and fundamental physics. Aims. We expand and adjust the mock Euclid likelihoods of t ...

The gravitationally lensed supernova Refsdal appeared in multiple images produced through gravitational lensing by a massive foreground galaxy cluster. After the supernova appeared in 2014, lens models of the galaxy cluster predicted that an additional ima ...

We investigate the role of dense environments in suppressing star formation by studying log(10)(M- * / M-?) > 9 . 7 star-forming galaxies in nine clusters from the Local Cluster Survey (0.0137 < z < 0.0433) and a large comparison field sample drawn from th ...

Surface stress drives long-range elastocapillary interactions at the surface of compliant solids, where it has been observed to mediate interparticle interactions and to alter the transport of liquid drops. We show that such an elastocapillary interaction ...

Whole genome doubling (WGD) events are drivers of genetic innovation across vertebrate evolution. While generally detrimental to mammalian organisms, WGDs are crucial in the development of various plants and fungi, as well as for the terminal differentiati ...

The HST treasury programme BUFFALO provides extended wide-field imaging of the six Hubble Frontier Fields galaxy clusters. Here we present the combined strong and weak-lensing analysis of Abell 370, a massive cluster at z = 0.375. From the reconstructed to ...

The radial metallicity distribution of the Milky Way's disc is an important observational constraint for models of the formation and evolution of our Galaxy. It informs our understanding of the chemical enrichment of the Galactic disc and the dynamical pro ...

We have identified 189 candidate z > 1.3 protoclusters and clusters in the LSST Deep Drilling Fields. This sample will enable the measurement of the metal enrichment and star formation history of clusters during their early assembly period through the dire ...

DNA-binding proteins physically interact with the DNA and directly affect genomic functions. The eukaryotic genome is compacted into chromatin, limiting the DNA access to nuclear factors. In this Ph.D. thesis, I explored the dynamic mechanisms, that allow ...

The PHANGS collaboration has been building a reference data set for the multiscale, multiphase study of star formation and the interstellar medium (ISM) in nearby galaxies. With the successful launch and commissioning of JWST, we can now obtain high-resolu ...

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

Nanostructured graphitic materials, including graphene hosting Å to nanometer-sized pores, have attracted attention for various applications such as separations, sensors, and energy storage. Graphene with Å-scale pores is a promising next-generation materi ...

Tidal dwarf galaxies (TDGs) are low-mass objects that form within tidal and/or collisional debris ejected from more massive interacting galaxies. We use CO(1-0) observations from Atacama Large Millimeter/submillimeter Array and integral-field spectroscopy ...

KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

Chat with Graph Search

Heartbeat on repeat: noncanonical KZFP and its transposable element targets shape cardiac cell specification

Structural basis of SIRT7 nucleosome engagement and substrate specificity

Individual transcription factors modulate both the micromovement of chromatin and its long-range structure

Hydrodynamical simulations of merging galaxy clusters: giant dark matter particle colliders, powered by gravity

The effect of pressure-anisotropy-driven kinetic instabilities on magnetic field amplification in galaxy clusters

Hidden Gems on a Ring: Infant Massive Clusters and Their Formation Timeline Unveiled by ALMA, HST, and JWST in NGC 3351

CURLING - I. The influence of point-like image approximation on the outcomes of cluster strong lens modelling

Euclid: Validation of the MontePython forecasting tools

Constraints on the Hubble constant from supernova Refsdal's reappearance

The Local Cluster Survey II: disc-dominated cluster galaxies with suppressed star formation

Elastocapillary menisci mediate interaction of neighboring structures at the surface of a compliant solid

Whole genome doubling promotes tumorigenesis through loss of chromatin segregation and compartment repositioning

Beyond the ultradeep frontier fields and legacy observations (BUFFALO): a high-resolution strong plus weak-lensing view of Abell 370

The evolution of the Milky Way's thin disc radial metallicity gradient with K2 asteroseismic ages

Spitzer-selected z > 1.3 protocluster candidates in the LSST Deep Drilling Fields

Development of multiplexed single-molecule imaging techniques to study chromatin invasion dynamics of chromatin effector proteins

The PHANGS-JWST Treasury Survey: Star Formation, Feedback, and Dust Physics at High Angular Resolution in Nearby GalaxieS

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Mechanistic study on the evolution of vacancies in graphene by oxidation by scanning tunneling microscopy

Molecular and ionized gas in tidal dwarf galaxies: the spatially resolved star formation relation