Publication

System and Method For In Vivo Delivery of Antibodies and Fragments Thereof

Patrick Aebischer, Maurizio Molinari, Nicolas Bouche
2011
Patents

Abstract

The present invention is directed to devices and methods for in situ delivering an antibody or a fragment thereof to a host. In particular, the invention relates to devices and methods for in situ delivering an antibody or a fragment thereof to patient suffering for a neurodegenerative disorder or other diseases treated by antibody administration.

Official source

https://infoscience.epfl.ch/entities/publication/29cbfdc3-6265-4a8b-87e9-bfceb9939c59

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Patrick Aebischer, Maurizio Molinari, Nicolas Bouche
2011
Patents

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/29cbfdc3-6265-4a8b-87e9-bfceb9939c59

About this result

Related concepts (32)

Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision.

Monoclonal antibody

A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell. Monoclonal antibodies can have monovalent affinity, binding only to the same epitope (the part of an antigen that is recognized by the antibody). In contrast, polyclonal antibodies bind to multiple epitopes and are usually made by several different antibody-secreting plasma cell lineages.

Iterative method

In computational mathematics, an iterative method is a mathematical procedure that uses an initial value to generate a sequence of improving approximate solutions for a class of problems, in which the n-th approximation is derived from the previous ones. A specific implementation with termination criteria for a given iterative method like gradient descent, hill climbing, Newton's method, or quasi-Newton methods like BFGS, is an algorithm of the iterative method.

Related publications (32)

System and Method For In Vivo Delivery of Antibodies and Fragments Thereof

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