Publication

Recognition and response to microbial infection in Drosophila

2009
Book Chapters

Abstract

This chapter discusses the mechanisms whereby Drosophila recognize foreign microbes, the signalling systems that regulate adapted responses against them, and the effector mechanisms used to control them. It first focuses on the so-called systemic antimicrobial response. The second section of the chapter looks at local immune response, particularly gut epithelial immunity. The final section of the chapter discusses current research themes exploring the integration of local and systemic immunity, as well as their integration in host physiology

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2009
Book Chapters

Abstract

Official source

Related concepts (30)

Innate immune system

The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).

Adaptive immune system

The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.

Immune system

The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli.

Related publications (12)

Recognition and response to microbial infection in Drosophila

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Advanced human lung organoids-on-a-chip to model epithelial-immune responses to viral infection

A Glycosylation-Dependent Checkpoint Restrains Intestinal Intra-Epithelial Lymphocyte Activation

Engineered DCs reprogram the TME to unleash immunotherapy and CAR-T efficacy in lung cancer models