Publication

Accessing CF3-Cyclopropenes ─ A Platform for the Synthesis of Trifluoromethylated Building Blocks

2025

Abstract

Cyclopropenes are the smallest unsaturated carbocycles. They possess exceptionally high ring strain, resulting in unique reactivity, enabling C═C bond functionalization and ring-opening transformations. Herein, we report a copper-mediated trifluoromethylation of cyclopropenyl benziodoxole (CpBX) reagents, providing access to previously inaccessible, yet highly useful, sp2-trifluoromethylated cyclopropenes. Subsequent functionalizations of these novel strained ring building blocks enable access to highly substituted trifluoromethylated cyclopropanes, difluoromethylene cyclopropanes and noncyclic trifluoromethylated compounds.

Official source

https://infoscience.epfl.ch/entities/publication/27bf129f-48bd-42e7-a9e0-dbc7d45528fd

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2025

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/27bf129f-48bd-42e7-a9e0-dbc7d45528fd

About this result

Related concepts (6)

Chemical bond

A chemical bond is a lasting attraction between atoms or ions that enables the formation of molecules, crystals, and other structures. The bond may result from the electrostatic force between oppositely charged ions as in ionic bonds, or through the sharing of electrons as in covalent bonds. The strength of chemical bonds varies considerably; there are "strong bonds" or "primary bonds" such as covalent, ionic and metallic bonds, and "weak bonds" or "secondary bonds" such as dipole–dipole interactions, the London dispersion force, and hydrogen bonding.

Access control

In physical security and information security, access control (AC) is the selective restriction of access to a place or other resource, while access management describes the process. The act of accessing may mean consuming, entering, or using. Permission to access a resource is called authorization. Locks and login credentials are two analogous mechanisms of access control. Physical security Geographical access control may be enforced by personnel (e.g. border guard, bouncer, ticket checker), or with a device such as a turnstile.

Discretionary access control

In computer security, discretionary access control (DAC) is a type of access control defined by the Trusted Computer System Evaluation Criteria (TCSEC) as a means of restricting access to objects based on the identity of subjects and/or groups to which they belong. The controls are discretionary in the sense that a subject with a certain access permission is capable of passing that permission (perhaps indirectly) on to any other subject (unless restrained by mandatory access control).