Publications related to Minimally Invasive and in Situ Capacitive Sensing of Cardiac Troponin I From Interstitial Fluid

Related publications (18)

Lumped Parameter Modeling of the Hypoplastic Left Heart Syndrome During Birth

Hypoplastic left heart syndrome (HLHS) is a congenital heart disease characterized by the underdevelopment of left heart structures. Previous studies using lumped-parameter models focused on extreme cases where the left ventricle is absent. We propose a mo ...

Springer Science and Business Media Deutschland GmbH2025

AI-Based Estimation of End-Systolic Elastance From Arm-Pressure and Systolic Time Intervals

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas, Stamatia Zoi Pagoulatou

Left ventricular end-systolic elastance (Ees) is a major determinant of cardiac systolic function and ventricular-arterial interaction. Previous methods for the Ees estimation require the use of the echocardiographic ejection fraction (EF). However, given ...

2021

Heart Rate Variability Triangular Index as a Predictor of Cardiovascular Mortality in Patients With Atrial Fibrillation

Jean-Marc Vesin, Vincent Schlageter

Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed in patients with atrial fibrillation (AF). We hypothesized that parameters of HRV may be predictive o ...

2020

Cardiac Ambulatory Monitoring: New Wireless Device Validated Against Conventional Holter Monitoring in a Case Series

Srinivasan Murali, Francisco Javier Rincon Vallejos

Background: Cardiac arrhythmias are very common but underdiagnosed due to their transient and asymptomatic nature. An optimization of arrhythmia detection would permit to better treat patients and could substantially reduce morbidity and mortality. The Sma ...

FRONTIERS MEDIA SA2020

Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1(+) epicardial cells

Na Li, Alexia Laurie Carboni

Brain natriuretic peptide (BNP) treatment increases heart function and decreases heart dilation after myocardial infarction (MI). Here, we investigated whether part of the cardioprotective effect of BNP in infarcted hearts related to improved neovascularis ...

2020

Computational fluid dynamics of blood flow in an idealized left human heart

Alfio Quarteroni, Filippo Menghini

We construct an idealized computational model of the left human heart for the study of the blood flow dynamics in the left atrium and ventricle. We solve the Navier-Stokes equations in the ALE formulation and we prescribe the left heart wall displacement b ...

Wiley2019

Taming the viscoelastic creep of dielectric elastomer actuators

Herbert Shea, Samuel Rosset, Alexandre Poulin

We present a simple open-loop method to suppress the viscoelastic drift of dielectric elastomer actuators (DEAs). Viscoelastic creep is one of the drawbacks of DEAs, especially when made with acrylic elastomer membranes (VHB). This leads to a time-dependen ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Estimating Left Ventricular Elastance from Aortic Flow Waveform, Ventricular Ejection Fraction, and Brachial Pressure: An In Silico Study

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou

Although left ventricular end-systolic elastance (E-es) serves as a major index of cardiac contractility, a widely-accepted noninvasive estimation of E-es does not exist. To overcome this limitation, we developed a two-step inverse method that allows for i ...

SPRINGER2018

Nanoscale Sensors for Ultrasensitive Label-free Detection of Cancer Biomarkers and Monitoring of Therapeutic Compounds

Ioulia Tzouvadaki

Prostate cancer is a life-threatening malignant disease, one the most common cancer types in men and leading cause of death among men because of cancer. Considering the state of the art for the diagnosis of prostate cancer a man overall has to suffer uncom ...

EPFL2017

Computational study of the risk of restenosis in coronary bypasses

Alfio Quarteroni, Christian Vergara

Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall exce ...

Springer Heidelberg2017

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper, Jie Zhang

The most important physiological mechanism mediating enhanced exercise performance is increased sympathetic, beta adrenergic receptor (beta-AR), and adenylyl cyclase (AC) activity. This is the first report of decreased AC activity mediating increased exerc ...

Wiley-Blackwell2015

A 1024-sample serum analyzer chip for cancer diagnostics

Sebastian Maerkl

We present a platform that combines microarrays and microfluidic techniques to measure four protein biomarkers in 1024 serum samples for a total of 4096 assays per device. Detection is based on a surface fluorescence sandwich immunoassay with a limit of de ...

Royal Society of Chemistry2014

Novel ECG and Intracardiac Electrograms Signal Processing Schemes for Predicting the Outcome of Atrial Fibrillation Catheter Ablation

Andréa Buttu

Atrial fibrillation (AF) is the most common encountered cardiac rhythm disorder (arrhythmia) in clinical practice. It is responsible for about one third of arrhythmia-related hospitalizations. This arrhythmia, which increases in prevalence with age, leads ...

EPFL2014

Generic and patient-specific models of the arterial tree

Nikolaos Stergiopoulos, Philippe Reymond, Orestis Vardoulis

Recent advance in imaging modalities used frequently in clinical routine can provide description of the geometrical and hemodynamical properties of the arterial tree in great detail. The combination of such information with models of blood flow of the arte ...

Springer Netherlands2012

Partitioned Solution of Geometrical Multiscale Problems for the Cardiovascular System : Models, Algorithms, and Applications

Adelmo Cristiano Innocenza Malossi

The aim of this work is the development of a geometrical multiscale framework for the simulation of the human cardiovascular system under either physiological or pathological conditions. More precisely, we devise numerical algorithms for the partitioned so ...

EPFL2012

An investigation into therapies for atrial arrythmias using a biophysical model of the human atria

Lam Dang

The most common type of sustained arrhythmia is atrial fibrillation (AF), affecting about 2% of the general population and 8% to 11% of the elderly, more than 65 years of age. The treatment of atrial arrythmia is still based on empirical considerations and ...

EPFL2006

Myocardial Motion Analysis from B-Mode Echocardiograms

Michaël Unser, Michael Sühling, Muthuvel Arigovindan

The quantitative assessment of cardiac motion is a fundamental concept to evaluate ventricular malfunction. We present a new optical-flow-based method for estimating heart motion from two-dimensional echocardiographic sequences. To account for typical hear ...

IEEE2005

Nonlinear isochrones in murine left ventricular pressure-volume loops: how well does the time-varying elastance concept hold?

Nikolaos Stergiopoulos

The linear time-varying elastance theory is frequently used to describe the change in ventricular stiffness during the cardiac cycle. The concept assumes that all isochrones (i.e., curves that connect pressure-volume data occurring at the same time) are li ...

2005