Publication

Self-assembly of rod-coil diblock oligomers based on α-helical peptides

2001
Journal Articles

Abstract

A detailed study of the supramolecular organization of two series of peptide-based diblock oligomers is reported. The diblock oligomers are comprised of an α-helical oligopeptide rod, which is either based on γ-benzyl-L-glutamate or ε-benzyloxycarbonyl-L-lysine, and a short oligo(styrene) coil. The unique feature of these rod-coil molecules is that the conformation of the α-helical peptide rod is sensitive to temperature. As a result, the supramolecular organization of these rod-coil oligomers can be manipulated not only via changes in the block length ratio or chemical composition but also via temperature-induced conformational changes in the rod segments. This makes these molecules attractive building blocks for the development of stimuli-sensitive self-assembled materials.

Official source

https://infoscience.epfl.ch/entities/publication/24f384fe-4d16-46e2-8dba-387eea52a74f

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2001
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/24f384fe-4d16-46e2-8dba-387eea52a74f

About this result

Related concepts (32)

Molecular self-assembly

In chemistry and materials science, molecular self-assembly is the process by which molecules adopt a defined arrangement without guidance or management from an outside source. There are two types of self-assembly: intermolecular and intramolecular. Commonly, the term molecular self-assembly refers to the former, while the latter is more commonly called folding. Molecular self-assembly is a key concept in supramolecular chemistry. This is because assembly of molecules in such systems is directed through non-covalent interactions (e.

Self-assembly

Self-assembly is a process in which a disordered system of pre-existing components forms an organized structure or pattern as a consequence of specific, local interactions among the components themselves, without external direction. When the constitutive components are molecules, the process is termed molecular self-assembly. Self-assembly can be classified as either static or dynamic. In static self-assembly, the ordered state forms as a system approaches equilibrium, reducing its free energy.

Self-assembly of nanoparticles

Nanoparticles are classified as having at least one of three dimensions be in the range of 1-100 nm. The small size of nanoparticles allows them to have unique characteristics which may not be possible on the macro-scale. Self-assembly is the spontaneous organization of smaller subunits to form larger, well-organized patterns. For nanoparticles, this spontaneous assembly is a consequence of interactions between the particles aimed at achieving a thermodynamic equilibrium and reducing the system’s free energy.

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Self-assembly of rod-coil diblock oligomers based on α-helical peptides

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