Publication

1,2,4-Tris(trifluoromethyl)benzene: selective lithiation and subsequent electrophilic substitution

Manfred Schlosser
1998
Journal Articles

Abstract

1,2,4-Tris(trifluoromethyl)benzene quant. undergoes a hydrogen/metal exchange when treated with an ethereal soln. of lithium 2,2,6,6-tetramethylpiperidide. Proton abstraction occurs concomitantly from positions 5 and 6, the ratios varying from 80:20 to 90:10, depending on the reaction conditions. Pure 5-iodo-1,2,4-tris(trifluoromethyl)benzene was readily obtained by fractional crystn. of the regioisomeric mixt. and was used to prep. 5-substituted derivs. of 1,2,4-tris(trifluoromethyl)benzene by consecutive reaction with tert-butyllithium and an electrophile. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/24e77d67-fca2-4a46-a02c-438f7080ee43

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Manfred Schlosser
1998
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/24e77d67-fca2-4a46-a02c-438f7080ee43

About this result

Related concepts (20)

Chemical reaction

A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and breaking of chemical bonds between atoms, with no change to the nuclei (no change to the elements present), and can often be described by a chemical equation. Nuclear chemistry is a sub-discipline of chemistry that involves the chemical reactions of unstable and radioactive elements where both electronic and nuclear changes can occur.

Hydrogen

Hydrogen is the chemical element with the symbol H and atomic number 1. Hydrogen is the lightest element. At standard conditions hydrogen is a gas of diatomic molecules having the formula . It is colorless, odorless, tasteless, non-toxic, and highly combustible. Hydrogen is the most abundant chemical substance in the universe, constituting roughly 75% of all normal matter. Stars such as the Sun are mainly composed of hydrogen in the plasma state. Most of the hydrogen on Earth exists in molecular forms such as water and organic compounds.

Metal–organic framework

Metal–organic frameworks (MOFs) are a class of compounds consisting of metal clusters (also known as SBUs) coordinated to organic ligands to form one-, two-, or three-dimensional structures. The organic ligands included are sometimes referred to as "struts" or "linkers", one example being 1,4-benzenedicarboxylic acid (BDC). More formally, a metal–organic framework is an organic-inorganic porous extended structure. An extended structure is a structure whose sub-units occur in a constant ratio and are arranged in a repeating pattern.

Related publications (14)

1,2,4-Tris(trifluoromethyl)benzene: selective lithiation and subsequent electrophilic substitution

Chat with Graph Search

Ammonia‐Induced Metal–Organic Framework Membrane Pore Tuning for Hydrogen Separation

Bipolar plates in water electrolysis stacks: understanding basics and electrochemical aspects impacting the energy efficiency during operation

Enhancing CO2 hydrogenation to methanol in fixed and fluidized bed reactors by selective in-situ adsorption of water