Publication

Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds

Paul Joseph Dyson, Rosario Scopelliti, Kay Severin, Claudine Scolaro, Barnali Dutta
2008
Journal Articles

Abstract

The water-sol. complexes [(Cp'OR)RuCl(PTA)2] (Cp'OR = h5-1-alkoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl; R = Me, Et; PTA = 1,3,5-triaza-7-phosphaadamantane) are considerably more cytotoxic (.apprx.2 orders of magnitude) than the cyclopentadienyl analog [CpRuCl(PTA)2] (i.e., IC50 = 4-10 vs. >1000 mM, depending on the cell line). The structure of [(Cp'OMe)RuCl(PTA)2] is reported, together with that of the precursor [(Cp'OEt)Ru(m-Cl)]2.

Official source

https://infoscience.epfl.ch/entities/publication/240a709b-6712-4e73-9d95-c047a4cd1314

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Paul Joseph Dyson, Rosario Scopelliti, Kay Severin, Claudine Scolaro, Barnali Dutta
2008
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/240a709b-6712-4e73-9d95-c047a4cd1314

About this result

Related concepts (9)

Ferrocene

Ferrocene is an organometallic compound with the formula . The molecule is a complex consisting of two cyclopentadienyl rings bound to a central iron atom. It is an orange solid with a camphor-like odor, that sublimes above room temperature, and is soluble in most organic solvents. It is remarkable for its stability: it is unaffected by air, water, strong bases, and can be heated to 400 °C without decomposition. In oxidizing conditions it can reversibly react with strong acids to form the ferrocenium cation .

Rhodocene

Rhodocene is a chemical compound with the formula . Each molecule contains an atom of rhodium bound between two planar aromatic systems of five carbon atoms known as cyclopentadienyl rings in a sandwich arrangement. It is an organometallic compound as it has (haptic) covalent rhodium–carbon bonds. The radical is found above or when trapped by cooling to liquid nitrogen temperatures (). At room temperature, pairs of these radicals join via their cyclopentadienyl rings to form a dimer, a yellow solid.

Cyclopentadienyl complex

A cyclopentadienyl complex is a coordination complex of a metal and cyclopentadienyl groups (C5H5−, abbreviated as Cp−). Cyclopentadienyl ligands almost invariably bind to metals as a pentahapto (η5-) bonding mode. The metal–cyclopentadienyl interaction is typically drawn as a single line from the metal center to the center of the Cp ring. Biscyclopentadienyl complexes are called metallocenes. A famous example of this type of complex is ferrocene (FeCp2), which has many analogues for other metals, such as chromocene (CrCp2), cobaltocene (CoCp2), and nickelocene (NiCp2).

Related publications (19)

Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds

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