An energetic view of stress: Focus on mitochondria

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Geotechnical problems with total stress changes occurring rapidly relative to the soil consolidation time can be conveniently addressed using an effective stress-based approach. For saturated states, analytical formulations of pore-pressure coefficients ad ...

IntroductionOne-third of mothers rate their childbirth as traumatic. The prevalence of childbirth-related post-traumatic stress disorder (CB-PTSD) is 4.7%. Skin-to-skin contact is a protective factor against CB-PTSD. However, during a caesarean section (CS ...

Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...

Mitochondria are essential organelles participating in numerous cellular functions, including energy harvesting, regulation of homeostasis and apoptosis. Changes in mitochondrial number, morphology, and function not only impact cellular metabolism but also ...

Lignin hydrogenolysis is a key step in the sustainable production of renewable bio-based chemicals and fuels. Heterogeneous metal catalysts have led to high yields but they rapidly deactivate, notably due to nanoparticle sintering and carbonaceous deposit ...

The stress state is an important parameter in terms of both earthquake nucleation and rupture. Here, a new stimulation technique is proposed for Enhanced Geothermal Systems (EGSs), which have previously been burdened with a number of high-profile incidence ...

Redox homeostasis is a key factor in maintaining cellular function and health. The main determinant of the intracellular redox potential is ubiquitous glutathione (GSH) together with its oxidized dimer (GSSG). Importantly, both redox equilibrium and GSH ho ...

Human babies have a natural desire to interact with new toys and objects, through which they learn how the world around them works, e.g., that glass shatters when dropped, but a rubber ball does not. When their predictions are proven incorrect, such as whe ...

When brittle hydrogels fail, several mechanisms conspire to alter the state of stress near the tip of a crack, and it is challenging to identify which mechanism is dominant. In the fracture of brittle solids, a sufficient far-field stress results in the co ...

Glucose sensing in pancreatic D-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteo-mics to search for downstream effectors of glucose-dependent signal tran ...

Over the past two decades, the thermo-hydro-mechanical behavior of earth-contact structures such as piles, walls, slabs, and tunnels, which simultaneously provide structural support and energy supply, has been studied through various field experiments and ...

Our planet has been challenged for years by our reckless use of fossil fuels, which has led to the ongoing climate change and energy crisis. The transition to the use of renewable alternative sources has now became urgent and inevitable. The valorization o ...

Despite the wealth of research on smart cities, there is a lack of studies examining interlinkages between smart cities and Sustainable Development Goals (SDGs). In other words, there is limited research on how implementing smart city solutions can lead to ...

Regulation of mitochondrial redox balance is emerging as a key event for cell signaling in both physiological and pathological conditions. However, the link between the mitochondrial redox state and the modulation of these conditions remains poorly defined ...

In recent years, the automotive industry has aspired to bring self-driving vehicles to the general public and light detection and ranging (LiDAR) sensors have emerged as the preferred solution for car vision systems. At present, LiDAR technologies employ e ...

Reactive metabolites and related electrophilic drugs are among the most challenging small molecules to study. Conventional approaches to deconstruct the mode of action (MOA) of such molecules leverage bulk treatment of experimental specimens with an excess ...

Weber et al. provide evidence in support of a stress-diathesis model of functional neurological disorders. They identify trauma history in the form of emotional neglect as a psychological risk factor, and reduced hippocampus and amygdala volume as a predis ...

Background: 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated to a high risk for psychiatric disorders, including psychosis. Individuals with 22q11DS are thought to experience increased levels of chronic stress, which could lead to ...

Compacted scaly clays are complex geomaterials widely used for the realization of dam cores and waste dump liners. This research aims to investigate the swelling/shrinkage behavior of these geomaterials subjected in an oedometric cell to complex hydromecha ...

Individuals frequently differ in their behavioral and cognitive responses to stress. However, whether motivation is differently affected by acute stress in different individuals remains to be established. By exploiting natural variation in trait anxiety in ...

An energetic view of stress: Focus on mitochondria

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Pore-pressure coefficients for unsaturated soils: generalized effective stress approach

'connEcted caesarean section': creating a virtual link between MOthers and their infanTs to ImprOve maternal childbirth experieNce - study protocol for a PILOT trial (e-motion-pilot)

Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

Sinter-Resistant Nickel Catalyst for Lignin Hydrogenolysis Achieved by Liquid Phase Atomic Layer Deposition of Alumina

Single-Well Pore Pressure Preconditioning for Enhanced Geothermal System Stimulation

HaloTag-Based Tools for Live-Cell Imaging and Elucidation of Organellar Redox Biology

Seeking the new, learning from the unexpected: Computational models of surprise and novelty in the brain

Crack tip kinematics reveal the process zone structure in brittle fracture

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Thermo-hydro-mechanical behavior of energy barrettes: Field experiments and numerical simulations

Lignin, from biomass waste to sustainable materials for food packaging, antiviral coatings and agriculture

Smart cities and sustainable development goals (SDGs): A systematic literature review of co-benefits and trade-offs

The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state

GeSn as next-generation material for short-wave infrared single-photon detection

Monitoring On-Target Signaling Responses in Larval Zebrafish- Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites

Identification of biopsychological trait markers in functional neurological disorders

Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome

Role of Stress History on the Swelling-Shrinkage Behavior of Compacted Scaly Clay

Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA