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Prefrontal engrams of long-term fear memory perpetuate pain perception

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Bodily self-consciousness as a framework to link sensory information and self-related components of episodic memory: behavioral, neuroimaging, and clinical evidence

Nathalie Heidi Meyer

The recollection of sensory information and subjective experience related to a personal past event depends on our episodic memory (EM). At the neural level, EM retrieval is linked with the reinstatement of hippocampal activity thought to recollect the sens ...

EPFL2023

Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability

Maria del Carmen Sandi Perez, Olivia Zanoletti, Simone Astori, Jocelin Grosse, Marie-Isabelle Guillot de Suduiraut, Sophie Elizabeth Walker, Silvia Monari

Background: Understanding why only a subset of trauma-exposed individuals develop posttraumatic stress disorder is critical for advancing clinical strategies. A few behavioral (deficits in fear extinction) and biological (blunted glucocorticoid levels, sma ...

2023

Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen

Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The developing adolescent brain is highly sensitive to social experiences and environmental insults, influencing how personality traits emerge. A distinct patter ...

2023

From cellular to fear memory: An epigenetic toolbox to remember

Johannes Gräff, Davide Martino Coda

Throughout development, the neuronal epigenome is highly sensitive to external stimuli, yet capable of safeguarding cellular memory for a lifetime. In the adult brain, memories of fearful experiences are rapidly instantiated, yet can last for decades, but ...

Current Biology Ltd2023

2D Nanosystems: Applications of 2D Semiconductors for In-Memory Computing

Guilherme Migliato Marega

Machine learning and data processing algorithms have been thriving in finding ways of processing and classifying information by exploiting the hidden trends of large datasets. Although these emerging computational methods have become successful in today's ...

EPFL2023

Neuronal correlates of goal-directed sensorimotor transformation in sensory, motor and higher-order cortical areas

Anastasiia Oryshchuk

An important function of the brain is to interpret incoming sensory information from the outside world to guide adaptive behavior. Understanding how and where sensory information is transformed into motor commands in a context- and learning-dependent manne ...

EPFL2023

Where does the engram come from? Study of prefrontal cortex inputs during memory consolidation

Lucie Pauline Dixsaut

The formation and storage of memories has been under deep investigation for several decades. Nevertheless, the precise contribution of each brain region involved in this process and the interplay between them across memory consolidation is still largely de ...

EPFL2022

The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample

Farnaz Delavari

Multiple lines of evidence across human functional, lesion, and animal data point to a cerebellar role, in particular of crus I, crus II, and lobule VIIB, in cognitive function. However, a mapping of distinct facets of cognitive function to cerebellar stru ...

Springer2023

A Stand-Alone Augmented Reality Intervention for Chronic Pain using Embodied Systolic Stimulation

Andrea Serino, Robert Leeb, Oliver Alan Kannape, Skander Mensi, Sylvain Cardin

Chronic pain presents a tremendous personal, societal, and financial burden. Treatment options are often limited to managing symptoms as opposed to treating the causes, and the consequences of pharmacological treatments can be immensely harmful as evidence ...

IEEE2023

Brain-wide screen of prelimbic cortex inputs reveals a functional shift during early fear memory consolidation

Johannes Gräff, Lucie Pauline Dixsaut

Memory formation and storage rely on multiple interconnected brain areas, the contribution of which varies during memory consolidation. The medial prefrontal cortex, in particular the prelimbic cortex (PL), was traditionally found to be involved in remote ...

2022

An instance-based learning approach for evaluating the perception of ride-hailing waiting time variability

Michel Bierlaire

Understanding user’s perception of service variability is essential to discern their overall perception of any type of (transport) service. We study the perception of waiting time variability for ride-hailing services. We carried out a stated preference su ...

2023

Epigenetic plasticity as a signature for memory allocation

Giulia Santoni

Long-lasting memories are stored in a small set of neurons scattered throughout the brain, so-called engram cells. To define a stable engram each region of the brain involved in memory storage recruits between 5 and 20 percent of excitatory neurons. In par ...

EPFL2022

The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and intracellular communication after learning

Johannes Gräff, Jose Vicente Sanchez Mut, Giulia Santoni, Allison Marie Burns

Long-term memory formation relies on synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Multiple studies have shown that HDAC inhibitor (HDACi) treatments can enhance individual aspects of these processes and ...

2022

Me, Myself, and I: Neural Activity for Self versus Other across Development

Solange Noémie Jeanne Denervaud

Although adults and children differ in self-vs.-other perception, a developmental perspective on this discriminative ability at the brain level is missing. This study examined neural activation for self-vs.-other in a sample of 39 participants spanning fou ...

MDPI2023

Connecting the dots: harnessing dual-site transcranial magnetic stimulation to quantify the causal influence of medial frontal areas on the motor cortex

Pierre Theopistos Vassiliadis

Dual-site transcranial magnetic stimulation has been widely employed to investigate the influence of cortical structures on the primary motor cortex. Here, we leveraged this technique to probe the causal influence of two key areas of the medial frontal cor ...

Oxford Univ Press Inc2023

An insular cortex - lateral amygdala network in fear learning

Shriya Palchaudhuri

Animals are capable of evaluating sensory cues for possible threats and adapting their behaviours accordingly. Fear learning is an evolutionarily conserved behaviour crucial for animal survival, during which sensory percepts with a negative reinforcing qua ...

EPFL2022