Publications related to Multiscale modeling of lymphatic drainage from tissues using homogenization theory

Noise-induced transitions past the onset of a steady symmetry-breaking bifurcation: The case of the sudden expansion

François Gallaire, Edouard Boujo, Yves-Marie François Ducimetière

We consider fluid flows, governed by the Navier-Stokes equations, subject to a steady symmetry-breaking bifurcation and forced by a weak noise acting on a slow timescale. By generalizing the multiple-scale weakly nonlinear expansion technique employed in t ...

2024

Ultra-High Sensitivity Silicon Nanowire Array Biosensor Based on a Constant-Current Method for Continuous Real-Time pH and Protein Monitoring in Interstitial Fluid

Mihai Adrian Ionescu, Yann Christophe Sprunger, Ali Saeidi, Luca Capua

In this paper we demonstrate ultra-high sensitivity silicon nanowires pH and protein sensing on the same Silicon nanowire array platform by using a constant current method and monitoring the drain voltage as function of analyte concentration. The injected ...

IEEE2023

Monitoring of Protein and pH Levels in Human Biofluids using FD-SOI Silicon Nanowire Arrays

Luca Capua

Medical research and technological advancements are heading towards tailored healthcare approaches that prioritize individual needs, allowing for more accurate diagnoses, more effective treatments, and better patient outcomes overall. One such approach is ...

EPFL2023

Three-dimensional buoyant hydraulic fractures: finite volume release

Andreas Möri, Brice Tanguy Alphonse Lecampion

In impermeable media, a hydraulic fracture can continue to expand even without additional fluid injection if its volume exceeds the limiting volume of a hydrostatically loaded radial fracture. This limit depends on the mechanical properties of the surround ...

Cambridge University Press2023

Label-Free C-Reactive Protein Si Nanowire FET Sensor Arrays With Super-Nernstian Back-Gate Operation

Mihai Adrian Ionescu, Yann Christophe Sprunger, Luca Capua, Ron Gill, Aristea Grammoustianou, Felix Risch

We present a CMOS-compatible double gate and label-free C-reactive protein (CRP) sensor, based on silicon on insulator (SOI) silicon nanowires arrays. We exploit a reference subtracted detection method and a super-Nernstian internal amplification given by ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma

Li Tang, Bing Feng, Thomas Gruber

Background The use of intralesional Mycobacterium bovis BCG (intralesional live BCG) for the treatment of metastatic melanoma resulted in regression of directly injected, and occasionally of distal lesions. However, intralesional-BCG is less effective in p ...

BMJ PUBLISHING GROUP2022

Conjugate heat transfer in isolated granular clusters with interstitial fluid using lattice Boltzmann method

Mehrdad Kiani Oshtorjani

The conjugate heat transfer in mixtures of a fluid and single granular clusters is studied in this paper using a novel lattice Boltzmann method (LBM) programmed for parallel computation on the graphics processing unit (GPU). The LBM is validated for heat c ...

PERGAMON-ELSEVIER SCIENCE LTD2022

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Mauro Delorenzi, Alexis Rapin, Dominique Velin, Esther Bovay, François Renevey

The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain homeostasis remain elusive. We report that inactivation of the mechanosensitive transcription factor Foxc ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Numerical simulation of sediment dynamics with free surface flows

Arwa Mrad

We present a numerical model for the simulation of 3D mono-dispersed sediment dynamics in a Newtonian flow with free surfaces. The physical model is a macroscopic model for the transport of sediment based on a sediment concentration with a single momentum ...

EPFL2021

Hydraulic fracture growth in quasi-brittle materials

Dong Liu

Hydraulic fracturing is a technique often used in the oil and gas industry to enhance the production of wells in low-permeability reservoirs. It consists of fluid injection at a sufficiently large injection rate to create and propagate tensile fractures in ...

EPFL2021

Geometric mixing

Nicolas Piro Mastracchio

Mixing fluids often involves a periodic action, like stirring one's tea. But reciprocating motions in fluids at low Reynolds number, in Stokes flows where inertia is negligible, lead to periodic cycles of mixing and unmixing, because the physics, molecular ...

ROYAL SOC2020

Experimental studies of hydro-mechanical couplings in Enhanced Geothermal Reservoirs

Mateo Alejandro Acosta

Enhanced Geothermal Systems (EGS) allow for worldwide geothermal electricity production. They target deep (3-5 km), fractured rock reservoirs whose permeability is artificially increased through hydraulic stimulations (fluid injections). The injections mod ...

EPFL2020

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Melody Swartz, Alexandre de Titta, Witold Waldemar Kilarski, Sachiko Hirosue, Marcela Rincón-Restrepo, Esra Güç, David Scott Wilson

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...

Nature Research2020

Dynamic response of a compressible binary fluid mixture

Ignacio Pagonabarraga Mora

Binary fluids are present in a wide variety of systems at microscales, such as microfluidic devices containing drops, fluids with air bubbles trapped in them, and devices designed to mix fluids or to make two fluid substances react. Microfluidics devices a ...

2020

Nanoparticle-enhanced Imaging Based Plasmonic Biosensor

Alexander Belushkin

Efficient medical care fundamentally relies on the ability to provide a timely and accurate diagnosis. Thanks to advances in biomedical research, specific molecules called diagnostic molecular biomarkers have been discovered in the human body that help ind ...

EPFL2020

Experimental Drainage Device to Reduce Lymphoedema in a Rat Model

Nikolaos Stergiopoulos, Melody Swartz, Marco Pisano, Valentina Triacca

Objective: Despite recent advances in pharmacological research and microsurgery, lymphoedema remains an incurable disease that deeply affects quality of life. There is an urgent need for innovative approaches to restore continuous lymph flow in affected ti ...

2019

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

Melody Swartz, Davide Demurtas, Lambert Charles François Potin, Patricia Corthésy Henrioud, Léa Maillat, Romain Hamelin, Natacha Anne-Sophie Bordry, Maria Anna Sofia Broggi, Alexandre Harari

Liquid biopsies allow monitoring of cancer progression and detection of relapse, but reliable biomarkers in melanoma are lacking. Because secreted factors preferentially drain to lymphatic vessels before dilution in the blood, we hypothesized that lymph sh ...

ROCKEFELLER UNIV PRESS2019

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

Melody Swartz, Witold Waldemar Kilarski, Marco Pisano

Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine factors ...

Springer2019

Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation

Francesco Stellacci, Marie Mueller, Ye Yang, Ahmet Bekdemir

Although immunotherapy shows great promise for the long-term control of cancer, many tumors still fail to respond to treatment. To improve the outcome, the delivery of immunostimulants to the lymph nodes draining the tumor, where the antitumor immune respo ...

ELSEVIER SCI LTD2019

Collective behavior of red blood cells in confined channels

Ignacio Pagonabarraga Mora

We study the flow properties of red blood cells in confined channels, when the channel width is comparable to the cell size. We focus on the case of intermediate concentrations when hydrodynamic interactions between cells play a dominant role. This regime ...

2019