Publication

Dual-responsive polyphosphazene as a common platform for highly efficient drug self-delivery

2019
Journal Articles

Abstract

For clinical applications, simplicity, high efficiency, and low toxicity are key issues in the design of anti-tumor drugs. In this work, a novel dual-responsive drug self-framed delivery system (DSFDS) with high drug delivery efficiency is proposed based on self-framing of an anticancer drug and a tumor-responsive molecule within phosphazene nanoparticles through a simple condensation polymerization method under mild conditions. Due to a unique structural feature of polyphosphazenes, the nanodrug-delivery system showed pH responsiveness. Furthermore, the DSFDS was endowed with glutathione (GSH)-responsiveness by incorporating a cysteine derivative into the polyphosphazene nanoparticles. The dual-responsive DSFDS has been demonstrated to retain high stability during blood circulation and high sensitivity to tumor micromilieu (lower pH in lysosomes and higher GSH concentration in cytoplasm). A super high drug-loading capacity of over 78 wt% made it possible to reduce the usage of the drug and relieve metabolic stress. The proposed DSFDS showed promising potential for highly efficient and controllable release of cancer therapeutics.

Official source

https://infoscience.epfl.ch/entities/publication/1c72de57-7dc0-4b33-ab03-b9c6d2fb9664

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2019
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/1c72de57-7dc0-4b33-ab03-b9c6d2fb9664

About this result

Related concepts (31)

Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology.

Drug

A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhalation, injection, smoking, ingestion, absorption via a patch on the skin, suppository, or dissolution under the tongue. In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect.

Drug design

Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it.

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Dual-responsive polyphosphazene as a common platform for highly efficient drug self-delivery

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