Sexual selection shapes development and maturation rates in Drosophila

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The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine. The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...

Significant increases in sedimentation rate accompany the evolution of multicellularity. These increases should lead to rapid changes in ecological distribution, thereby affecting the costs and benefits of multicellularity and its likelihood to evolve. How ...

In a context where daily car use is a spontaneous and habitual choice for a wide majority of the population, the quality of the alternatives to individual motorized vehicles is a major factor in encouraging modal shift. The ease of access to public transpo ...

Demographic models of human cultural evolution have high explanatory potential but weak empirical support. Here we use a global dataset of rock art sites and climate and genetics-based estimates of ancient population densities to test a new model based on ...

Often, we intuitively assume that there are common factors in life. For example, we test people with a visual acuity test to determine whether they are allowed to drive a car or not- with the implicit assumption that the acuity test is representative of vi ...

Droplet microfluidics are characterized by the generation and manipulation of discrete volumes of solutions, generated with the use of immiscible phases. Those droplets can then be controlled, transported, analyzed or their content modified. In this wide d ...

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely ...

Chinese Hamster Ovary [CHO] cells are the workhorse for production of modern biopharmaceuticals. They are however immortalized cells with a high propensity for genetic change. Judging from published culture records, CHO cell populations have undergone hund ...

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Despite worldwide reports of high tree mortality, growing evidence indicates that many tree species are well adapted to survive repeated dry spells. The drought resilience of trees is related to their phenotypic plasticity and ecotypic differentiation. Whe ...

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A high-resolution reference panel based on whole-genome sequencing data enables accurate imputation of HLA alleles across diverse populations and fine-mapping of HLA association signals for HIV-1 host response. ...

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Simple Summary: After domestication in specific regions, livestock followed human migrations and colonized the whole world. During this population expansion, human and natural selection, together with demographic events, molded the livestock genome leading ...

Two-dimensional Fourier transform spectroscopy is a promising technique to study ultrafast molecular dynamics. Similar to transient absorption spectroscopy, a more complete picture of the dynamics requires broadband laser pulses to observe transient change ...

Sexual selection shapes development and maturation rates in Drosophila

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The genetic architecture of complex human traits at the dawn of genomic medicine

Regulation of sedimentation rate shapes the evolution of multicellularity in a close unicellular relative of animals

Assessment of the Bus Transit Network: A Perspective from the Daily Activity-Travel Organization of Travelers

Stabilization of cultural innovations depends on population density: Testing an epidemiological model of cultural evolution against a global dataset of rock art sites and climate-based estimates of ancient population densities

About common factors in vision

Microfluidic Device for Droplet Pairing by Combining Droplet Railing and Floating Trap Arrays

A platform for experimental precision medicine: The extended BXD mouse family

Naming CHO cells for bio-manufacturing: Genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names

KRAB zinc finger protein-mediated control of transposon-embedded regulatory sequences from human germline to early embryos

Phenotypic plasticity versus ecotypic differentiation under recurrent summer drought in two drought-tolerant pine species

A modular strategy for next-generation upper-limb sensory-motor neuroprostheses

Early detection and surveillance of SARS-CoV-2 genomic variants in wastewater using COJAC

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

GA4GH: International policies and standards for data sharing across genomic research and healthcare

The Quest for Genes Involved in Adaptation to Climate Change in Ruminant Livestock

Broadband visible two-dimensional spectroscopy of molecular dyes