Publications related to Real-time radiology in the microscale

3D printed large amplitude torsional microactuators powered by ultrasound

Mehdi Ali Gadiri, Mahmut Selman Sakar, Amit Yedidia Dolev, Junsun Hwang

Here, we introduce a design, fabrication, and control methodology for large amplitude torsional microactuators powered by ultrasound. The microactuators are 3D printed from two polymers with drastically different elastic moduli as a monolithic compliant me ...

2024

Tangentially viewing phase contrast imaging for turbulence measurements in toroidal fusion devices

Stefano Coda

Phase contrast imaging (PCI) is an established and powerful technique for measuring density fluctuations in plasmas and has been successfully applied to several fusion devices. Rooted in a concept first developed for microscopy, PCI belongs to the category ...

2024

A synthetic phase-contrast imaging diagnostic with spatial filtering for gyrokinetic simulations

Stephan Brunner, Stefano Coda, Gabriele Merlo, Aylwin Iantchenko, Justin Richard Ball

A Phase-contrast imaging (PCI) diagnostic provides measurements of line-integrated electron density fluctuations. Localisation along the laser beam path can be achieved with a spatial filter that selects the wave-vector directions of the fluctuations contr ...

2023

An optimal preconditioned FFT-accelerated finite element solver for homogenization

Till Junge, Ali Falsafi, Martin Ladecký

We generalize and provide a linear algebra-based perspective on a finite element (FE) ho-mogenization scheme, pioneered by Schneider et al. (2017)[1] and Leuschner and Fritzen (2018)[2]. The efficiency of the scheme is based on a preconditioned, well-scale ...

ELSEVIER SCIENCE INC2023

Phase Reconstruction of Low-Energy Electron Holograms of Individual Proteins

Klaus Kern, Stephan Rauschenbach, Sven Alexander Szilagyi, Hannah Julia Ochner

Low-energy electron holography (LEEH) is one of the few techniques capable of imaging large and complex three-dimensional molecules, such as proteins, on the single molecule level at subnanometer resolution. During the imaging process, the structural infor ...

AMER CHEMICAL SOC2022

High sensitivity, incoherent differential imaging

Chiara Bonati

Microscopic visualisation of optically transparent samples has been a topic of interest for several decades. Features such as density or chemical composition can influence the optical phase of transmitted light, and phase contrast can reveal these structur ...

EPFL2022

Multicore fiber endoscope for phase imaging based on intensity recording using deep neural networks

Navid Borhani, Demetri Psaltis, Christophe Moser, Eirini Kakkava

The present invention is related to an endoscopic system for phase imaging, comprising a multicore waveguide (080), an optical system comprising at least one first light source (002), for illuminating the sample to be examined, a first camera (010) that is ...

2022

Stain-free identification of cell nuclei using tomographic phase microscopy in flow cytometry

Demetri Psaltis, Joowon Lim, Daniele Pirone

The accurate identification of the three-dimensional quantitative shape of a cell nucleus is now possible without fluorescent staining by applying computational segmentation to refractive index tomograms recorded in the flow cytometry mode. ...

Nature Publishing Group2022

Lock-in incoherent differential phase contrast imaging

Christophe Moser, Damien Claude-Marie Loterie, Timothé Laforest, Chiara Bonati

We introduce a lock-in method to increase the phase contrast in incoherent differential phase contrast (DPC) imaging. This method improves the phase sensitivity by the analog removal of the background. The use of a smart pixel detector with in-pixel signal ...

CHINESE LASER PRESS2022

Lock-in amplified differential phase contrast

Christophe Moser, Damien Claude-Marie Loterie, Timothé Laforest, Chiara Bonati

We introduce a lock-in method to increase the phase contrast in incoherent Differential Phase Contrast (DPC) imaging. The use of a smart pixel detector with in-pixel signal demodulation, paired with synchronized illumination, provides the basis of a bit-ef ...

SPIE-INT SOC OPTICAL ENGINEERING2022

Nonlinear Inverse Problems in Quantitative Phase Imaging

Thanh-An Michel Pham

The topic of this thesis is the development of new algorithmic reconstruction methods for quantitative phase imaging (QPI). In the past decade, advanced QPI has emerged as a valuable tool to study label-free biological samples and uncover their 3D structur ...

EPFL2022

Beware of beam damage under reaction conditions: X-ray induced photochemical reduction of supported VOx catalysts during in situ XAS experiments

Oliver Kröcher, Davide Ferri, Anna Zabilska, Olga Safonova

In situ X-ray absorption spectroscopy (XAS) is a powerful technique for the investigation of heterogeneous catalysts and electrocatalysts. The obtained XAS spectra are usually interpreted from the point of view of the investigated chemical processes, there ...

ROYAL SOC CHEMISTRY2022

The new X-ray/visible microscopy MAXWELL technique for fast three-dimensional nanoimaging with isotropic resolution

Giorgio Margaritondo, Lin Yang

Microscopy by Achromatic X-rays With Emission of Laminar Light (MAXWELL) is a new X-ray/visible technique with attractive characteristics including isotropic resolution in all directions, large-volume imaging and high throughput. An ultrathin, laminar X-ra ...

Nature Portfolio2022

Advanced Techniques in Optical Diffraction Tomography

Ahmed Bassam Sayed Ayoub Mohamed Emam

In this thesis, we study the 3 challenges described above. First, we study different reconstruction techniques and assess the fidelity of each reconstruction results by means of structured illumination and phase conjugation. By reconstructing the 3D refrac ...

EPFL2022

Medipix4, a high granularity four sides buttable pixel readout chip for high resolution spectroscopic X-ray imaging at rates compatible with medical CT scans

Viros Sriskaran

Medipix4 is the latest member in the Medipix/Timepix family of pixel detector chips aimed at high rate spectroscopic X-ray imaging using high-Z materials. The chip address the limitations of conventional hybrid pixel detectors for X-ray imaging. Its predec ...

EPFL2022

Robust Phase Unwrapping via Deep Image Prior for Quantitative Phase Imaging

Matthias Lütolf, Michaël Unser, Nathalie Brandenberg, Thanh-An Michel Pham, Fangshu Yang

Quantitative phase imaging (QPI) is an emerging label-free technique that produces images containing morphological and dynamical information without contrast agents. Unfortunately, the phase is wrapped in most imaging system. Phase unwrapping is the comput ...

2021

In-operando dynamic visualization of flow through porous preforms based on X-ray phase contrast imaging

Véronique Michaud, Baris Çaglar, Helena Luisa Teixido Pedarros

Direct visualization is often sought to elucidate flow patterns and validate models to predict the filling kinetics during processes whereby a liquid resin infiltrates a textile porous preform. Here, X-ray phase contrast interferometry is evaluated to imag ...

2021

3D reconstruction of weakly scattering objects from 2D intensity-only measurements using the Wolf transform

Demetri Psaltis, Ahmed Ayoub, Joowon Lim, Elizabeth Elena Antoine

A new approach to optical diffraction tomography (ODT) based on intensity measurements is presented. By applying the Wolf transform directly to intensity measurements, we observed unexpected behavior in the 3D reconstruction of the sample. Such a reconstru ...

2021

Quantitative Microstructural Imaging for Clinical Use

Gian Franco Piredda

Today, Magnetic Resonance Imaging (MRI) is a well-established medical imaging modality thanks to its excellent soft tissue contrast. Conventional MR image contrasts can be weighted towards one or more physical properties that discriminate different tissues ...

EPFL2021

Polarization-sensitive optics diffraction tomography

Demetri Psaltis, Ahmed Ayoub, Joowon Lim, Elizabeth Elena Antoine, Amirhossein Saba Shirvan

Polarization of light has been widely used as a contrast mechanism in two-dimensional (2D) microscopy and also in some three-dimensional (3D) imaging modalities. In this paper, we report the 3D tomographic reconstruction of the refractive index (RI) tensor ...

2021