T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier

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Immunometabolites are capable of contributing to the intricate intercellular cytokine signaling networks through a variety of different mechanisms, which will be detailed in this chapter. Their ability to regulate cytokines in this manner has led to the no ...

Background The toxin α-amanitin from Amanita phalloides induces hepatocyte death and disrupts local and systemic immune responses, key drivers of acute liver failure (ALF). Although TNF-α plays a central role in ALF, TNF-α-targeted therapies alone have sho ...

Individuals differ widely in their immune responses, with age, sex and genetic factors having major roles in this inherent variability1–6. However, the variables that drive such differences in cytokine secretion—a crucial component of the host response to ...

As current chemo- and photodynamic cancer therapies are associated with severe side effects due to a lack of specificity and to systemic toxicity, innovative solutions in terms of targeting and controlled functionality are in high demand. Here, we present ...

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

In aqueous solutions, a charged surface causes the redistribution of nearby ions. The ion layers formed are known as the electrical double layer (EDL), and are widespread in many systems involving electrochemistry, colloidal science, biomedicine, and energ ...

Recent advances in coupling light-harvesting microorganisms with electronic components have led to a new generation of biohybrid devices based on microbial photocatalysts. These devices are limited by the poorly conductive interface between phototrophs and ...

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

Hydrogels are a class of soft materials, which display unique biomimetic properties to biological tissues. Their mechanical properties, high water content, and porosity resemble that of extracellular matrix so that cell growth and proliferation can be reli ...

The peripheral nervous system (PNS) regulates the exchange of sensory information and motor commands between the body and the central nervous system. Further, through the autonomic nervous system, the PNS plays a pivotal role in controlling vital physiolog ...

CD4+T cells orchestrate the adaptive immune response against pathogens and cancer by recognizing epitopes presented on class II major histocompatibility complex (MHC-II) molecules. The high polymorphism of MHC-II genes represents an important hurdle toward ...

Microsupercapacitors (with footprints from -mm up to -cm scale) have attracted attention for use as electrochemical energy storage devices to power wearables, IoT, and other small microsystems due to their high power density, excellent charge/discharge rev ...

In the context of transitioning toward a more sustainable use of natural resources, the application of lignin to substitute commonly utilized petroleum-based plastics can play a key role. Although lignin is highly available at low cost and presents interes ...

Supported Co-based catalysts exhibit promising catalytic activities in the oxygen evolution reaction (OER) during alkaline water electrolysis. Surface functionalization of the support modulates the dispersion of the catalysts and their interaction with the ...

Recent advances in the field of nanomaterials demonstrated how their use for vaccination can drastically improve immune responses, mainly by enhancing delivery and uptake of vaccine components. However, our understanding of the connections between presenta ...

The challenge of defining and cataloging the building blocks of the brain requires a standardized approach to naming neurons and organizing knowledge about their properties. The US Brain Initiative Cell Census Network, Human Cell Atlas, Blue Brain Project, ...

Precise control of bionic limbs relies on robust decoding of motor commands from nerves or muscles signals and sensory feedback from artificial limbs to the nervous system by interfacing the afferent nerve pathways. Implantable devices for bidirectional co ...

Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading pathogens. These genes commonly encode multiple products as post-translationally cleaved polypeptides. Recent studies have highlighted roles for AMPs in neurological contexts s ...

From surgery to watchmaking, fine-manipulation skills highly rely on the dexterity afforded by both hands. Coordination is key to human dexterity. Specifically, humans need not only to govern the abundant intrinsic degrees of freedom (DOFs) to allocate con ...

Chemical reactions and phase transformations in nanometer-size objects may happen at very short timescales, so conventional characterization tools are not applicable. A new technique combining high spatial and temporal resolution is ultrafast (or dynamic) ...

T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier

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Regulation of cytokine secretion by immunometabolites

Dual therapy for amanita phalloides-induced acute liver failure in mice: A combination of etanercept and alpha-1 antitrypsin

Smoking changes adaptive immunity with persistent effects

FAP Targeting of Photosensitizer-Loaded Polymersomes for Increased Light-Activated Cell Killing

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Second harmonic scattering of nanoparticles: A journey into the electrical double layer

In vivo polydopamine coating of Rhodobacter sphaeroides for enhanced electron transfer

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Hydrogels and conductive hydrogels for implantable bioelectronics

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

Additive Fabrication of Microsupercapacitors

Ductile, High-Lignin-Content Thermoset Films and Coatings

Understanding the role of surface oxygen-containing functional groups on carbon-supported cobalt catalysts for the oxygen evolution reaction

DNA-based biomaterials for nanoscale controlled modulation of immune cells

The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types

Bidirectional bionic limbs: a perspective bridging technology and physiology

Repeated truncation of a modular antimicrobial peptide gene for neural context

Enhancing our understanding of human fine manipulation skills and advancing robot dexterity in grasping

Analytics at the nanometer and nanosecond scales by short electron pulses in an electron microscope