Publication

Palladium-Catalyzed Aminocarbonylation of Alkynes to Succinimides

Paul Joseph Dyson, Huizhen Liu, Pui Shan Genevieve Lau
2015
Journal Articles

Abstract

Succinimide derivatives are useful building blocks for the synthesis of natural products and drugs. We describe an efficient route to succinimide derivatives comprising Pd(xantphos)Cl2-catalyzed aminocarbonylation of alkynes with aromatic or aliphatic amines in the presence of p-TsOH. The utility of this route is demonstrated with the synthesis of a large number of succinimide compounds including an important photochromic molecule.

Official source

https://infoscience.epfl.ch/entities/publication/19459084-9a9c-486a-99eb-9db5e68a66a4

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