Publication

Superbase reactions: the expedient and selective metalation of fluorine- or trifluoromethyl-substituted benzenes

Manfred Schlosser
1990
Journal Articles

Abstract

When treated with the superbasic mixt. of butyllithium and potassium tert-butoxide, fluorobenzene, difluorobenzenes, fluoro(trifluoromethyl)benzenes, (trifluoromethyl)benzene and bis(trifluoromethyl)benzenes undergo site-selective hydrogen-metal exchange. Best results are obtained in THF solns. at -75 Deg or -50 Deg. Upon quenching with carbon dioxide the corresponding carboxylic acids are obtained in good to excellent yield. [on SciFinder (R)]

Official source

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