Publication

Synthesis of Thiochromans via [3+3] Annulation of Aminocyclopropanes with Thiophenols

Jérôme Waser
2020
Journal Articles

Abstract

We report the one-pot synthesis of 4-amino thiochromans using simple aminocyclopropanes and thiophenols through a formal [3+3] annulation reaction. This reaction proceeds under mild conditions with good functional group tolerance. The thiochroman core was formed with complete regioselectivity, and modification of complex drug molecules containing an aminocyclopropane was also realized.

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Synthesis of Thiochromans via [3+3] Annulation of Aminocyclopropanes with Thiophenols

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