AlgorithmIn mathematics and computer science, an algorithm (ˈælɡərɪðəm) is a finite sequence of rigorous instructions, typically used to solve a class of specific problems or to perform a computation. Algorithms are used as specifications for performing calculations and data processing. More advanced algorithms can use conditionals to divert the code execution through various routes (referred to as automated decision-making) and deduce valid inferences (referred to as automated reasoning), achieving automation eventually.
Bernoulli processIn probability and statistics, a Bernoulli process (named after Jacob Bernoulli) is a finite or infinite sequence of binary random variables, so it is a discrete-time stochastic process that takes only two values, canonically 0 and 1. The component Bernoulli variables Xi are identically distributed and independent. Prosaically, a Bernoulli process is a repeated coin flipping, possibly with an unfair coin (but with consistent unfairness). Every variable Xi in the sequence is associated with a Bernoulli trial or experiment.
Binomial distributionIn probability theory and statistics, the binomial distribution with parameters n and p is the discrete probability distribution of the number of successes in a sequence of n independent experiments, each asking a yes–no question, and each with its own Boolean-valued outcome: success (with probability p) or failure (with probability ). A single success/failure experiment is also called a Bernoulli trial or Bernoulli experiment, and a sequence of outcomes is called a Bernoulli process; for a single trial, i.
Clinical trialClinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought.
Gibbs' inequalityIn information theory, Gibbs' inequality is a statement about the information entropy of a discrete probability distribution. Several other bounds on the entropy of probability distributions are derived from Gibbs' inequality, including Fano's inequality. It was first presented by J. Willard Gibbs in the 19th century. Suppose that is a discrete probability distribution. Then for any other probability distribution the following inequality between positive quantities (since pi and qi are between zero and one) holds: with equality if and only if for all i.
Laplace transformIn mathematics, the 'Laplace transform, named after its discoverer Pierre-Simon Laplace (ləˈplɑ:s), is an integral transform that converts a function of a real variable (usually , in the time domain) to a function of a complex variable (in the complex frequency domain, also known as s-domain', or s-plane). The transform has many applications in science and engineering because it is a tool for solving differential equations. In particular, it transforms ordinary differential equations into algebraic equations and convolution into multiplication.
Qualitative variationAn index of qualitative variation (IQV) is a measure of statistical dispersion in nominal distributions. There are a variety of these, but they have been relatively little-studied in the statistics literature. The simplest is the variation ratio, while more complex indices include the information entropy. There are several types of indices used for the analysis of nominal data. Several are standard statistics that are used elsewhere - range, standard deviation, variance, mean deviation, coefficient of variation, median absolute deviation, interquartile range and quartile deviation.
Total correlationIn probability theory and in particular in information theory, total correlation (Watanabe 1960) is one of several generalizations of the mutual information. It is also known as the multivariate constraint (Garner 1962) or multiinformation (Studený & Vejnarová 1999). It quantifies the redundancy or dependency among a set of n random variables. For a given set of n random variables , the total correlation is defined as the Kullback–Leibler divergence from the joint distribution to the independent distribution of , This divergence reduces to the simpler difference of entropies, where is the information entropy of variable , and is the joint entropy of the variable set .
Heuristic (psychology)Heuristics is the process by which humans use mental short cuts to arrive at decisions. Heuristics are simple strategies that humans, animals, organizations, and even machines use to quickly form judgments, make decisions, and find solutions to complex problems. Often this involves focusing on the most relevant aspects of a problem or situation to formulate a solution. While heuristic processes are used to find the answers and solutions that are most likely to work or be correct, they are not always right or the most accurate.
Adaptive design (medicine)In an adaptive design of a clinical trial, the parameters and conduct of the trial for a candidate drug or vaccine may be changed based on an interim analysis. Adaptive design typically involves advanced statistics to interpret a clinical trial endpoint. This is in contrast to traditional single-arm (i.e. non-randomized) clinical trials or randomized clinical trials (RCTs) that are static in their protocol and do not modify any parameters until the trial is completed.
Hellinger distanceIn probability and statistics, the Hellinger distance (closely related to, although different from, the Bhattacharyya distance) is used to quantify the similarity between two probability distributions. It is a type of f-divergence. The Hellinger distance is defined in terms of the Hellinger integral, which was introduced by Ernst Hellinger in 1909. It is sometimes called the Jeffreys distance. To define the Hellinger distance in terms of measure theory, let and denote two probability measures on a measure space that are absolutely continuous with respect to an auxiliary measure .
Randomized algorithmA randomized algorithm is an algorithm that employs a degree of randomness as part of its logic or procedure. The algorithm typically uses uniformly random bits as an auxiliary input to guide its behavior, in the hope of achieving good performance in the "average case" over all possible choices of random determined by the random bits; thus either the running time, or the output (or both) are random variables.
