Publication

Modelling of Protein Palmitoylation Networks

2014
Posters

Abstract

S-Palmitoylation is a post-translational modification consisting in the reversible attachment of palmitate. Little is known about the mechanisms that underlie the dynamics of the process. Using computational modelling we investigated the palmitoylation- depalmitoylation cycles of the ER chaperone calnexin, which requires palmitoylation on 2 sites to be functional. Model based analysis revealed that palmitoylation seems to be an inefficient process where 75% of synthesized calnexin is degraded before it reaches the palmitoylated state. The model also shows that by tuning palmitoyltransferase activity, cells can regulate the abundance of calnexin. This raises the possibility that this apparent inefficiency is a design principle: palmitoylation is timed by a regulatory system that determines cellular calnexin content at the post-transcriptional level.

Official source

https://infoscience.epfl.ch/entities/publication/1747dfbb-1dd3-4c0d-bd4e-ad588b6d2bc9

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

2014
Posters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/1747dfbb-1dd3-4c0d-bd4e-ad588b6d2bc9

About this result

Related concepts (32)

Transcriptional regulation

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity. A single gene can be regulated in a range of ways, from altering the number of copies of RNA that are transcribed, to the temporal control of when the gene is transcribed. This control allows the cell or organism to respond to a variety of intra- and extracellular signals and thus mount a response.

Ras GTPase

Ras, from "Rat sarcoma virus", is a family of related proteins that are expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in three-dimensional structure and regulate diverse cell behaviours.

Transcription (biology)

Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules called non-coding RNAs (ncRNAs). mRNA comprises only 1–3% of total RNA samples. Less than 2% of the human genome can be transcribed into mRNA (Human genome#Coding vs. noncoding DNA), while at least 80% of mammalian genomic DNA can be actively transcribed (in one or more types of cells), with the majority of this 80% considered to be ncRNA.

Related publications (3)

Modelling of Protein Palmitoylation Networks

Chat with Graph Search

A needed nomenclature for nucleosomes

RDHK Family, Regulators dedicated to Organohalide Respiration - Sequence Diversity and Functional Prediction

Autophagy-independent LC3 function in vesicular traffic