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It has been known for more than 150 years that action effects in bridges due to traffic action are higher than it has to be expected for purely static loads. In the design of road bridges, this difference is considered by multiplying static traffic loads with a "dynamic amplification factor". The amplification factors defined in codes are based on dynamic load tests on existing bridges. Despite of hundreds of tests in several countries, experimental investigation has not given satisfactory explanation of the observed phenomena, which has resulted in marked differences between amplification factors defined in different codes. This is due to the fact that the core of the matter – the dynamic interaction between vehicles and bridges– is a complex mechanical problem. Based on a detailed analysis it is shown in the introduction, that it can also be attributed to the fact, that the experimental investigation is more part of the problem than its solution. This thesis aims at getting a solid and systematic grounding in the problem using theoretical analysis. The centre of attention is the question, which importance dynamic phenomena have in those scenarios which are effectively relevant for the structural safety of a bridge. All scenarios are considered that justify an amplification factor, and not only dynamic vehicle – bridge interaction. The structural safety evaluation of a bridge includes the verification of the ultimate and the fatigue limit state. Accordingly, this thesis distinguishes between the interaction at ultimate limit state, for which inelastic bridge behaviour is assumed, and the interaction at service limit state with linear elastic bridge behaviour. The structural analysis of a bridge shows in addition, that the elements of the bridge deck differ considerably from the main girders: For the elements of the deck – i.e. primarily for the deck slab – dynamic interaction is of little importance, and amplification of action effects is essentially due to amplification of traffic action. In the case of the main girders, action effects are additionally amplified due to the oscillations of the structure. In order to analyse interaction at service limit state in detail, very sophisticated models are required, which do not only cover all relevant eigenmodes of the bridge but also the non-linear, dynamic behaviour of heavy vehicles and the precise road surface profile. Design and analysis of such models are mostly conferred to specialists in numeric analysis and structural dynamics. In the contrary, this thesis aims at capturing the fundamental connections by simple models, which facilitates the identification of the key parameters and the interpretation of their influence. The most important result of the analysis of vehicle – bridge interaction at service limit state is that the amplification factor is most influenced by the weight and the number of vehicles on a bridge. Whereas the amplification is negligible for high vehicle loads, tests with r