Publication

Tag, you're it: G-ICAT identifies p120-cysteine glutathionylation triggering E-cadherin destabilization

Yimon Aye, Kevin Timothy Fridianto
2023

Abstract

Current methods have limited ability in directly quantifying the extent of glutathionylation on specific proteincysteines. In this issue of Cell Chemical Biology, Ahn et al.1 report G-ICAT (glutathione-based isotope-coded affinity tag), aimed at addressing this limitation. G-ICAT identifies Cysteine-692 within p120-catenin-a member of cadherin complex essential for cell-cell-contact maintenance-where C692-specific glutathionylation promotes E-cadherin destabilization.

Official source

https://infoscience.epfl.ch/entities/publication/1546b2b6-3054-4906-ac19-4da55358742c

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Tag, you're it: G-ICAT identifies p120-cysteine glutathionylation triggering E-cadherin destabilization

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