Publication

Multi-mode CMOS Implementation of Prostate Cancer Diagnostics with In-memory Sensing and Edge Computing

2026

Abstract

This paper proposes a novel 180 nm CMOS implementation of a device for a direct prostate cancer risk computation based on the simultaneous measurement and analysis of Prostate Specific Antigen (PSA) and its membrane isoform (PSMA) using in-memory sensing and computing. A comprehensive performance evaluation was performed by considering a stimulation period of 1 s, including post-layout extraction (PEX) simulations and process corner variations. The circuit was tested with the antigen concentrations of up to 10 fM, confirming its suitability for real-time diagnostics and precise biosensing.

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2026

Abstract

Official source

Related concepts (32)

Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.

Prostate

The prostate (ˈprɒs.teɪt) is both an accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation. It is found in all male mammals. It differs between species anatomically, chemically, and physiologically. Anatomically, the prostate is found below the bladder, with the urethra passing through it. It is described in gross anatomy as consisting of lobes and in microanatomy by zone. It is surrounded by an elastic, fibromuscular capsule and contains glandular tissue, as well as connective tissue.

CMOS

Complementary metal–oxide–semiconductor (CMOS, pronounced "sea-moss", siːmɑːs, -ɒs) is a type of metal–oxide–semiconductor field-effect transistor (MOSFET) fabrication process that uses complementary and symmetrical pairs of p-type and n-type MOSFETs for logic functions. CMOS technology is used for constructing integrated circuit (IC) chips, including microprocessors, microcontrollers, memory chips (including CMOS BIOS), and other digital logic circuits.

Related publications (6)

Multi-mode CMOS Implementation of Prostate Cancer Diagnostics with In-memory Sensing and Edge Computing

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