From Hebb rules to Spike-Timing-Dependent Plasticity: a personal account

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As the demand for high channel counts and high-resolution recordings of neural activity continues to grow, the increased power and data rate generated impose hard constraints on the telemetry capabilities of wireless implantable neural interfaces. To addre ...

Proprioception tells the brain the state of the body based on distributed sensory neurons. Yet, the principles that govern proprioceptive processing are poorly understood. Here, we employ a task -driven modeling approach to investigate the neural code of p ...

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

In computational neuroscience, multicompartment models are among the most biophysically realistic representations of single neurons. Constructing such models usually involves the use of the patch-clamp technique to record somatic voltage signals under diff ...

The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and w ...

While sensory representations in the brain depend on context, it remains unclear how such modulations are implemented at the biophysical level, and how processing layers further in the hierarchy can extract useful features for each possible contex-tual sta ...

Population equations for infinitely large networks of spiking neurons have a long tradition in theoret-ical neuroscience. In this work, we analyze a recent generalization of these equations to populations of finite size, which takes the form of a nonlinear ...

Prismatic slip in magnesium at temperatures T

All functions we use in our everyday life depend on a complex interplay between both cortical and subcortical brain areas, communicating in between each others. When a region is affected by either an accident, aging or neurodegenerative diseases, the whole ...

Developing spinal circuits generate patterned motor outputs while many neurons with high membrane resistances are still maturing. In the spinal cord of hatchling frog tadpoles of unknown sex, we found that the firing reliability in swimming of inhibitory i ...

How does reliable computation emerge from networks of noisy neurons? While individual neurons are intrinsically noisy, the collective dynamics of populations of neurons taken as a whole can be almost deterministic, supporting the hypothesis that, in the br ...

Objective: Depotentiation of homosynaptic plasticity of the primary motor cortex (M1) is impaired in patients with Parkinson's disease (PD) who have developed dyskinesias. In this exploratory study, we tested whether this holds true for heterosynaptic plas ...

Understanding how neural circuits remodel and adapt to animal behavior is a central theme in the field of Neuroscience. One strategy to reach this goal is to repeatedly record the same animal's neural circuits and observe how they adapt when facing differe ...

High-strength metal alloys achieve their performance via careful control of precipitates and solutes. The nucleation, growth, and kinetics of precipitation, and the resulting mechanical properties, are inherently atomic scale phenomena, particularly during ...

The decline of neuronal synapses is an established feature of ageing accompanied by the diminishment of neuronal function, and in the motor system at least, a reduction of behavioural capacity. Here, we have investigated Drosophila motor neuron synaptic te ...

Objective: Ultrasound (US) stimulation carries the promise of a selective, reversible, and non-invasive modulation of neural activity without the need for genetic manipulation of neural structures. However, the mechanisms of US-induced generation of action ...

Recently the building of large neuronal circuits from realistic neuron models has gained traction. This bottom-up approach relies on the accurate description of the primitive elements composing the brain such as neurons and astrocytes, that are then aggreg ...

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

Mouse primary somatosensory barrel cortex (wS1) processes whisker sensory information, receiving input from two distinct thalamic nuclei. The first-order ventral posterior medial (VPM) somatosensory thalamic nucleus most densely innervates layer 4 (L4) bar ...

Objective. Deep brain stimulation (DBS) of basal ganglia effectively tackles motor symptoms of movement disorders such as Tourette syndrome (TS). The precise location of target stimulation site determines the range of clinical outcome in DBS patients, and ...

From Hebb rules to Spike-Timing-Dependent Plasticity: a personal account

Chat with Graph Search

A Reconfigurable High-Dynamic Range ∆Σ Front-End with Event-Based Decimation for Bandwidth-Efficient Implantable Neural Interfaces

Task-driven neural network models predict neural dynamics of proprioception

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala

NMDA-driven dendritic modulation enables multitask representation learning in hierarchical sensory processing pathways

On a Finite-Size Neuronal Population Equation

A low-temperature prismatic slip instability in Mg understood using machine learning potentials

Noninvasive deep brain stimulation to modulate human behavior by means of transcranial temporal interference electrical stimulation

Mechanisms Underlying the Recruitment of Inhibitory Interneurons in Fictive Swimming in Developing Xenopus laevis Tadpoles

Taming neuronal noise with large networks

Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia

Methods for acute and long-term imaging of the ventral nerve cord in behaving adult Drosophila

Neural Network Potentials for Age Hardening Aluminum Alloys

Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing

Ultrasound Stimulations Induce Prolonged Depolarization and Fast Action Potentials in Leech Neurons

Data driven building of realistic neuron model using IBEA and CMA evolution strategies

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex

Spatio-temporal structure of single neuron subthalamic activity identifies DBS target for anesthetized Tourette syndrome patients