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New water-soluble 3,5,6-bicyclophosphite ligands based on glucose modified with uracil, 5-fluorouracil or thymine are reported. The phosphite ligands were subsequently reacted with bis[dichlorido(η6-p-cymene)ruthenium(II)] and trirutheniumdodecacarbonyl to afford monoruthenium analogues of RAPTA-C and triruthenium clusters with 1–3 phosphite ligands, respectively. The influence of ligands on the stability of the compounds and the antiproliferative activity of the compounds was investigated.
Florence Pojer, Kelvin Ka Ching Lau, Julien Racle, David Gfeller, Philippe Guillaume Coune, Amédé Noredine Larabi
Bart Deplancke, Wouter Jozef L Saelens