Publication

Functionalization of the Sugar Moiety of Oligoribonucleotides on Solid Support

1999
Journal Articles

Abstract

A solid-phase method for the introduction of a variety of different side chains into oligoribonucleotides is presented. It is based on a b-D-allofuranosyl phosphoramidite with a bromopentyl-substituent tethered to the 6'-O position. After its incorporation into fully protected, immobilized RNA sequences, the bromine was substituted with a variety of soft nucleophiles which, in some cases, allowed further transformations. After deprotection and detachment, the corresponding functionalized oligoribonucleotides were purified and characterized. Incorporation of such side chains led to a slight lowering of transition temps., but some of them led to a significant enthalpic stabilization of an A-type RNA duplex. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/11a385b5-050d-42fb-a4ea-6dffbb5913e6

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1999
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/11a385b5-050d-42fb-a4ea-6dffbb5913e6

About this result

Related concepts (21)

Solid-phase synthesis

In chemistry, solid-phase synthesis is a method in which molecules are covalently bound on a solid support material and synthesised step-by-step in a single reaction vessel utilising selective protecting group chemistry. Benefits compared with normal synthesis in a liquid state include: High efficiency and throughput Increased simplicity and speed The reaction can be driven to completion and high yields through the use of excess reagent. In this method, building blocks are protected at all reactive functional groups.

Solid-state chemistry

Solid-state chemistry, also sometimes referred as materials chemistry, is the study of the synthesis, structure, and properties of solid phase materials. It therefore has a strong overlap with solid-state physics, mineralogy, crystallography, ceramics, metallurgy, thermodynamics, materials science and electronics with a focus on the synthesis of novel materials and their characterization. A diverse range of synthetic techniques, such as the ceramic method and chemical vapour depostion, make solid-state materials.

Solid

Solid is one of the four fundamental states of matter (the others being liquid, gas, and plasma). The molecules in a solid are closely packed together and contain the least amount of kinetic energy. A solid is characterized by structural rigidity (as in rigid bodies) and resistance to a force applied to the surface. Unlike a liquid, a solid object does not flow to take on the shape of its container, nor does it expand to fill the entire available volume like a gas.

Related publications (2)

Functionalization of the Sugar Moiety of Oligoribonucleotides on Solid Support

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Nanoelectronic devices comprising patterned thin films and method for producing the same