The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis

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Two fundamental properties of embryonic stem cells (ESCs) are their ability to self-renew and differentiate into all somatic cell types. Maintenance of their identity faces major challenges when transitioning through mitosis, as most DNA-binding proteins a ...

Etoposide (ETO) and methotrexate (MTX) are widely used chemotherapy drugs in cancer treatment, targeting specific cellular processes crucial for DNA replication and cell division. Despite their efficacy, both drugs have significant adverse toxic effects du ...

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Hydrated lipid bilayer membranes are crucial components of cells and organelles, serving as the outer boundary that separates the cellular components from the extracellular environment. Lipid membranes regulate their structures and functions by dynamically ...

We propose Reconfigurable Umbrella Meshes (RUMs), a new class of preassembled deployable structures. A RUM has a compact rest state that can be easily altered to deploy into different bending-active 3D target shapes. RUMs consist of elastic beams and rigid ...

Why biological quality-control systems fail is often mysterious. Specifically, checkpoints such as the DNA damage checkpoint or the spindle assembly checkpoint are overriden after prolonged arrests allowing cells to continue dividing despite the continued ...

Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize cellular heterogeneity(1). However, scRNA-seq requires lysing cells, which impedes further molecular or functional analyses on the same cells. Here, we established Liv ...

In most metazoans, centrioles are lost during oogenesis, ensuring that the zygote is endowed with the correct number of two centrioles, which are paternally contributed. How centriole architecture is dismantled during oogenesis is not understood. Here, we ...

The ratio of nuclear content to cytoplasmic volume (N/C ratio) is a key regulator driving the maternal-to -zy-gotic transition in most animal embryos. Altering this ratio often impacts zygotic genome activation and de-regulates the timing and outcome of em ...

Recognition of pathogen-derived molecules through germline-encoded receptors is a fundamental principle of innate immunity. Pattern recognition receptors detect specific intracellular danger signals to trigger potent immune responses. The DNA sensor cyclic ...

Cancer immunotherapy is the science of boosting the immune response of patients to fight cancer. Recent advances have brought up treatments with huge success in the clinic. Patients with ad-vanced-stage cancers were long-term cured through checkpoint inhib ...

Fluorescent D-amino acids (FDAAs) have previ-ously been developed to enable in situ highlighting of locations of bacterial cell wall growth. Most bacterial cells lie at the edge of the diffraction limit of visible light; thus, resolving the precise details ...

The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis

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Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

Simultaneous and Selective Detection of Etoposide and Methotrexate With Single Electrochemical Sensors for Therapeutic Drug Monitoring

Regulation of sedimentation rate shapes the evolution of multicellularity in a close unicellular relative of animals

Effects of thermal, mechanical, and electrostatic perturbations on lipid membrane hydration investigated by second harmonic imaging

RUM: Reconfigurable Umbrella Mesh

Principles of checkpoint override

Live-seq enables temporal transcriptomic recording of single cells

Centriole elimination during Caenorhabditis elegans oogenesis initiates with loss of the central tube protein SAS-1

The nuclear-to-cytoplasmic ratio drives cellularization in the close animal relative Sphaeroforma arctica

Exploring the mechanisms governing nuclear cGAS localization and activity

Development of stimuli-responsive chemistry for tumor-targeted immunotherapy

Fluorescent D-Amino Acids for Super-resolution Microscopy of the Bacterial Cell Wall