Publication

Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera

Yimon Aye, Kuan-Ting Huang, Sruthi Raja
2021
Journal Articles

Abstract

The mechanism-of-action of many electrohilic drugs remains poorly understood. Here, the authors use a redox-targeting approach to elucidate the basis for the innate immune cell toxicity of dimethyl fumarate, showing that it modifies Keap1 to trigger mitochondrial-targeted neutrophil/macrophage apoptosis.

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Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera

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