Publication

Gene therapy and bioengineering for retinal diseases: what is the future?

2015
Talks

Abstract

Sight restoration after retinal degeneration still represents an unmet goal. Since therapeutic strategies increasingly require interdisciplinary competencies, photoreceptor degeneration is attracting several research areas, including: life science, material science, engineering, and clinical science. Gene therapy, optogenetics, and neural prostheses are just few examples of research fields benefiting from multidisciplinary research. This talk will provide a broad description of the current approaches applied to the restoration of sight from the bio- and neuro-engineering point of view, with particular emphasis on gene correction and therapy. Moreover, I will highlight future directions involving engineering science in this exciting path towards sight restoration.

Official source

https://infoscience.epfl.ch/entities/publication/10595b6d-49fc-4721-b9a3-4476e3ca6397

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2015
Talks

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/10595b6d-49fc-4721-b9a3-4476e3ca6397

About this result

Related concepts (32)

Macular degeneration

Macular degeneration, also known as age-related macular degeneration (AMD or ARMD), is a medical condition which may result in blurred or no vision in the center of the visual field. Early on there are often no symptoms. Over time, however, some people experience a gradual worsening of vision that may affect one or both eyes. While it does not result in complete blindness, loss of central vision can make it hard to recognize faces, drive, read, or perform other activities of daily life. Visual hallucinations may also occur.

Retinal detachment

Retinal detachment is a disorder of the eye in which the retina peels away from its underlying layer of support tissue. Initial detachment may be localized, but without rapid treatment the entire retina may detach, leading to vision loss and blindness. It is a surgical emergency. The retina is a thin layer of light-sensitive tissue on the back wall of the eye. The optical system of the eye focuses light on the retina much like light is focused on the film in a camera.

Gene therapy of the human retina

Retinal gene therapy holds a promise in treating different forms of non-inherited and inherited blindness. In 2008, three independent research groups reported that patients with the rare genetic retinal disease Leber's congenital amaurosis had been successfully treated using gene therapy with adeno-associated virus (AAV). In all three studies, an AAV vector was used to deliver a functional copy of the RPE65 gene, which restored vision in children suffering from LCA.

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Gene therapy and bioengineering for retinal diseases: what is the future?

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