Repeated truncation of a modular antimicrobial peptide gene for neural context

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Immunometabolites are capable of contributing to the intricate intercellular cytokine signaling networks through a variety of different mechanisms, which will be detailed in this chapter. Their ability to regulate cytokines in this manner has led to the no ...

Background The toxin α-amanitin from Amanita phalloides induces hepatocyte death and disrupts local and systemic immune responses, key drivers of acute liver failure (ALF). Although TNF-α plays a central role in ALF, TNF-α-targeted therapies alone have sho ...

Background: Antibiotics save lives but also carry significant risks, including increased antimicrobial resistance, higher healthcare costs, and disruption of the microbiome. However, the association between antibiotic exposure and short-term adverse outcom ...

Individuals differ widely in their immune responses, with age, sex and genetic factors having major roles in this inherent variability1–6. However, the variables that drive such differences in cytokine secretion—a crucial component of the host response to ...

Genomic instability enhances cancer progression by favoring clonal diversity, yet uncontrolled replicative stress can lead to mitotic catastrophe and inflammatory responses promoting immune rejection. KRAB-containing zinc finger proteins (KZFPs) are epigen ...

The peripheral nervous system (PNS) regulates the exchange of sensory information and motor commands between the body and the central nervous system. Further, through the autonomic nervous system, the PNS plays a pivotal role in controlling vital physiolog ...

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

CD4+T cells orchestrate the adaptive immune response against pathogens and cancer by recognizing epitopes presented on class II major histocompatibility complex (MHC-II) molecules. The high polymorphism of MHC-II genes represents an important hurdle toward ...

Hydrogels are a class of soft materials, which display unique biomimetic properties to biological tissues. Their mechanical properties, high water content, and porosity resemble that of extracellular matrix so that cell growth and proliferation can be reli ...

Mitohormesis defines the increase in fitness mediated by adaptive responses to mild mitochondrial stress. Tetracyclines inhibit not only bacterial but also mitochondrial translation, thus imposing a low level of mitochondrial stress on eukaryotic cells. We ...

Viruses rely on the reprogramming of cellular processes to enable efficient viral replication; this often requires subcompartmentalization within the host cell. Liquid-liquid phase separation (LLPS) has emerged as a fundamental principle to organize and su ...

Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...

Recent advances in the field of nanomaterials demonstrated how their use for vaccination can drastically improve immune responses, mainly by enhancing delivery and uptake of vaccine components. However, our understanding of the connections between presenta ...

Precise control of bionic limbs relies on robust decoding of motor commands from nerves or muscles signals and sensory feedback from artificial limbs to the nervous system by interfacing the afferent nerve pathways. Implantable devices for bidirectional co ...

The challenge of defining and cataloging the building blocks of the brain requires a standardized approach to naming neurons and organizing knowledge about their properties. The US Brain Initiative Cell Census Network, Human Cell Atlas, Blue Brain Project, ...

Repeated truncation of a modular antimicrobial peptide gene for neural context

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Regulation of cytokine secretion by immunometabolites

Dual therapy for amanita phalloides-induced acute liver failure in mice: A combination of etanercept and alpha-1 antitrypsin

Absence of association between early antibiotic exposure and short-term adverse outcomes in very preterm infants: a single-center retrospective study

Smoking changes adaptive immunity with persistent effects

KRAB zinc finger proteins link heterochromatin maintenance to replicative stress and inflammation in diffuse large B-cell lymphoma

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

Hydrogels and conductive hydrogels for implantable bioelectronics

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

Phase separation in viral infections

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

DNA-based biomaterials for nanoscale controlled modulation of immune cells

Bidirectional bionic limbs: a perspective bridging technology and physiology

The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types