Publication

ID: 337509 A computational model of porcine vagus nerve stimulation and compound action potential sensing

2024

Abstract

Vagus nerve stimulation (VNS) is a promising treatment for several cardiac conditions. The effectiveness of VNS can be enhanced by increasing the selectivity of fiber activation. However, the vagus nerve activation profile depends on intra-subject variability in nerve (micro-)anatomy and neural interface implantation characteristics. Closed-loop neurostimulation may help to improve selectivity, but the compound action potential (CAP) signal is difficult to interpret. In this study, we simulate simultaneous stimulation and recording of a porcine vagus nerve using a Vagal Regenerative Autonomic Interface (VRAI) interfascicular electrode and a cuff electrode, respectively, in order to facilitate interpretation of the CAP.

Official source

https://infoscience.epfl.ch/entities/publication/0e0de232-fc77-42f4-ab27-bb23fc0c1169

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2024

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/0e0de232-fc77-42f4-ab27-bb23fc0c1169

About this result

Related concepts (32)

Vagus nerve

The vagus nerve, also known as the tenth cranial nerve, cranial nerve X, or simply CN X, is a cranial nerve that carries sensory fibers that create a pathway that interfaces with the parasympathetic control of the heart, lungs, and digestive tract. It comprises two nerves—the left and right vagus nerves—but they are typically referred to collectively as a single subsystem. The vagus is the longest nerve of the autonomic nervous system in the human body and comprises both sensory and motor fibers.

Nerve

A nerve is an enclosed, cable-like bundle of nerve fibers (called axons) in the peripheral nervous system. Axons transmit electrical impulses. Nerves have historically been considered the basic units of the peripheral nervous system. A nerve provides a common pathway for the electrochemical nerve impulses called action potentials that are transmitted along each of the axons to peripheral organs or, in the case of sensory nerves, from the periphery back to the central nervous system.

Deep brain stimulation

Deep brain stimulation (DBS) is a neurosurgical procedure involving the placement of a medical device called a neurostimulator, which sends electrical impulses, through implanted electrodes, to specific targets in the brain (the brain nucleus) for the treatment of movement disorders, including Parkinson's disease, essential tremor, dystonia, and other conditions such as obsessive-compulsive disorder (OCD) and epilepsy. While its underlying principles and mechanisms are not fully understood, DBS directly changes brain activity in a controlled manner.

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ID: 337509 A computational model of porcine vagus nerve stimulation and compound action potential sensing

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