The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

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Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-based ...

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Pancreatic beta cells play a major role in the regulation of glucose homeostasis by secreting insulin in response to elevated blood glucose levels. A gradual deterioration of functional beta cell mass and the chronic elevation of blood glucose levels are c ...

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Approximately 2 billion people worldwide and a significant part of the domestic livestock are infected with soil-transmitted helminths, of which many establish chronic infections causing substantial eco-nomic and welfare burdens. Beside intensive research ...

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

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Optimality principles for the analysis of biological processes across scales: From enzyme kinetics to microbiome dynamics

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Modeling, analysis, and design of complex biological networks

Detecting the metabolism of individual yeast mutant strain cells when aged, stressed or treated with antioxidants with diamond magnetometry

Social isolation shortens lifespan through oxidative stress in ants

Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population

GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity

Creating the conditions for Western European petroculture: The Marshall Plan, the politics of the OEEC, and the transition from coal to oil

Inter- and intra-individual variability in CO2 production and metabolic rate

Secondary structure of the human mitochondrial genome affects formation of deletions

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans

Machine learning-derived gut microbiome signature predicts fatty liver disease in the presence of insulin resistance

Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal

The role of nicotinamide riboside metabolism in pancreatic beta cells

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Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner