Normalization of network generalized extreme value models

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Digitised Newspapers – A New Eldorado for Historians? Reflections on Tools, Methods and Epistemology

The application of digital technologies to historical newspapers has changed the research landscape historians were used to. An Eldorado? Despite undeniable advantages, the new digital affordance of historical newspapers also transforms research practices ...

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DNA-based nanomaterials are gaining popularity as uniform and programmable bioengineering tools as a result of recent solutions to their weak stability under biological conditions. The DNA nanotechnology platform uniquely allows decoupling of engineering p ...

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Capturing trade-offs between daily scheduling choices

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We propose a new modelling approach for daily activity scheduling which integrates the different daily scheduling choice dimensions (activity participation, location, schedule, duration and transportation mode) into a single optimisation problem. The funda ...

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Optimization and equilibrium problems with discrete choice models

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Many transportation markets are characterized by oligopolistic competition. In these markets customers, suppliers and regulators make decisions that are influenced by the preferences and the decisions of all other agents. In particular, capturing and under ...

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Representing location choice within activity-based models

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Since the 70s, there has been a growing interest in activity-based modelling. This approach models the need to travel as a result of performing daily activities (Bowman and Ben-Akiva, 2001). Nevertheless, the activities need to be scheduled which involves ...

2022

A Modular Workflow for Model Building, Analysis, and Parameter Estimation in Systems Biology and Neuroscience

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Neuroscience incorporates knowledge from a range of scales, from single molecules to brain wide neural networks. Modeling is a valuable tool in understanding processes at a single scale or the interactions between two adjacent scales and researchers use a ...

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Automated Design: A Journey Across Modelling, Optimization, and Education

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Machine intelligence greatly impacts almost all domains of our societies. It is profoundly changing the field of mechanical engineering with new technical possibilities and processes. The education of future engineers also needs to adapt in terms of techni ...

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Quantification of Strand Accessibility in Biostable DNA Origami with Single-Staple Resolution

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DNA-based nanostructures are actively gaining interest as tools for biomedical and therapeutic applications following the recent development of protective coating strategies prolonging structural integrity in physiological conditions. For tailored biologic ...

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