Publication

Transition Metal-Free Intermolecular alpha-C-H Amination of Ethers at Room Temperature

Xile Hu, Ivan Buslov
2014
Journal Articles

Abstract

We describe a new method for the intermolecular amination of the alpha-C-H bonds of ethers. A hypervalent iodine reagent was used as oxidant to enable the amination of cyclic and acyclic alkyl ethers with a wide range of amides, imides, and amines. The amination occurred at room temperature and without a transition metal catalyst. The method could be used to synthesize the anti-cancer prodrug Tegafur and its analogues.

Official source

https://infoscience.epfl.ch/entities/publication/0a0ee159-4716-45fe-830f-7759dfd49945

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Transition Metal-Free Intermolecular alpha-C-H Amination of Ethers at Room Temperature

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