Publications related to A method for fast automated assessment of the magnetic resonance parkinsonism index

Related publications (41)

Simulation-based Microstructure Imaging: Towards Realistic White Matter Modeling using Monte Carlo Methods in DW-MRI

Over the last two decades, Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) has been developed as a powerful MR imaging modality that allows estimating non-invasively the microscopic structure of biological tissues by exploiting the natural motion of ...

EPFL2025

Enhancing skin lesion classification: a CNN approach with human baseline comparison

Zaffar Ahmed Shaikh

This study presents an augmented hybrid approach for improving the diagnosis of malignant skin lesions by combining convolutional neural network (CNN) predictions with selective human interventions based on prediction confidence. The algorithm retains high ...

PeerJ2025

Multimodal closed-loop strategies for gait recovery after spinal cord injury and stroke via the integration of robotics and neuromodulation

Simone Romeni, Valeria De Seta

Restoring the ability to walk is a priority for individuals with neurological disorders or neurotraumatic injuries, given its significant impact on independence and quality of life. Multimodal closed-loop strategies that integrate robotic assistance and ne ...

2025

Towards personalized mapping through lumbosacral spinal cord task fMRI

Dimitri Nestor Alice Van De Ville, Nawal Noëlle Kinany, Ilaria Ricchi

The lumbosacral spinal cord contains neural circuits crucial for locomotion, organized into rostrocaudal levels with distinct somatosensory and motor neuron pools that project to and from the muscles of the lower limbs. However, the specific spinal levels ...

2025

X-ray imaging detector for radiological applications adapted to the context and requirements of low- and middle-income countries

Jean-Philippe Thiran, René Salathé, Klaus Benedikt Schönenberger, Mario Andres Chavarria Varon, Hubert Lucien Blanchard, Sébastien Emmanuel Blanc

This paper describes the development of a novel medical x-ray imaging system adapted to the needs and constraints of low- and middle-income countries. The developed system is based on an indirect conversion chain: a scintillator plate produces visible ligh ...

2022

Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson's Disease and Multiple System Atrophy

Hilal Lashuel, Melek Firat Altay

Aggregated alpha-synuclein (alpha-synuclein) is the main component of Lewy bodies (LBs), Lewy neurites (LNs), and glial cytoplasmic inclusions (GCIs), which are pathological hallmarks of idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA ...

MDPI2022

Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies

Hilal Lashuel, Pedro José Santana Ribeiro Magalhães

Parkinson's disease (PD), the second most common progressive neurodegenerative disease, develops and progresses for 10-15 years before the clinical diagnostic symptoms of the disease are manifested. Furthermore, several aspects of PD pathology overlap with ...

NATURE PORTFOLIO2022

3-Dimensional Fluid and White Matter Suppression Magnetic Resonance Imaging Sequence Accelerated With Compressed Sensing Improves Multiple Sclerosis Cervical Spinal Cord Lesion Detection Compared With Standard 2-Dimensional Imaging

Tobias Kober

Objectives Fluid and white matter suppression (FLAWS) is a recently proposed magnetic resonance sequence derived from magnetization-prepared 2 rapid acquisition gradient-echo providing 2 coregistered datasets with white matter- and cerebrospinal fluid-supp ...

LIPPINCOTT WILLIAMS & WILKINS2022

Variability and reproducibility of multi-echo T2 relaxometry: Insights from multi-site, multi-session and multi-subject MRI acquisitions

Jean-Philippe Thiran, Tobias Kober, Friedhelm Christoph Hummel, Alessandro Daducci, Tom Hilbert, Gabriel Girard, Erick Jorge Canales Rodriguez, Marco Pizzolato, Takuya Morishita, Maximilian Jonas Wessel, Chang-Hyun Park, Elda Fischi Gomez, Thomas Yu, Elena Beanato, Gian Franco Piredda, Andéol Geoffroy Cadic-Melchior, Philipp Johannes Koch, Julia Brügger

Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in physical units, with normative values acqu ...

2022

Learning to sample in Cartesian MRI

Thomas Sanchez

Magnetic Resonance Imaging (MRI) is a non-invasive, non-ionizing imaging modality with unmatched soft tissue contrast. However, compared to imaging methods like X-ray radiography, MRI suffers from long scanning times, due to its inherently sequential acqui ...

EPFL2022

Choreography Controlled (ChoCo) brain MRI artifact generation for labeled motion-corrupted datasets

François Lazeyras, Michel Kocher, Sébastien Courvoisier

MRI is a non-invasive medical imaging modality that is sensitive to patient motion, which constitutes a major limitation in most clinical applications. Solutions may arise from the reduction of acquisition times or from motion-correction techniques, either ...

ELSEVIER SCI LTD2022

Effect of Lower Limb vs. Abdominal Compression on Mobility in Orthostatic Hypotension: A Single-Blinded, Randomized, Controlled, Cross-Over Pilot Study in Parkinson's Disease

Kamiar Aminian, Arash Atrsaei

Background: Orthostatic hypotension (OH) in Parkinson's disease (PD) is frequent and associated with impairments in quality of life and reduced activities of daily living. Abdominal binders (AB) and compression stockings (CS) have been shown to be effectiv ...

IOS PRESS2022

Chemically disruptable molecule switch and use thereof

Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui

The invention relates to chemically disruptable molecule (CDM) switch, their use in controlling cell signaling components, and their use for treatments and therapies. Further disclosed are methods of treating and/or preventing a disease, such as e.g. a can ...

2024

Self-Attentive Spatial Adaptive Normalization for Cross-Modality Domain Adaptation

Jean-Philippe Thiran, Seyedbehzad Bozorgtabar, Guillaume Marc Georges Vray, Devavrat Tomar, Manana Lortkipanidze

Despite the successes of deep neural networks on many challenging vision tasks, they often fail to generalize to new test domains that are not distributed identically to the training data. The domain adaptation becomes more challenging for cross-modality m ...

Institute of Electrical and Electronics Engineers2021

Simulated Half-Fourier Acquisitions Single-shot Turbo Spin Echo (HASTE) of the Fetal Brain: Application to Super-Resolution Reconstruction

Tobias Kober, Meritxell Bach Cuadra, Patric Hagmann, Reto Meuli, Tom Hilbert, Thomas Yu

Accurate characterization of in utero human brain maturation is critical as it involves complex interconnected structural and functional processes that may influence health later in life. Magnetic resonance imaging is a powerful tool complementary to the u ...

SPRINGER INTERNATIONAL PUBLISHING AG2021

Development and clinical validation of computational imaging biomarkers for neurodegenerative diseases

Veronica Lily Ravano

Neurodegenerative and neuroinflammatory disorders often involve complex pathophysiological mechanisms that are â to this date â only partially understood. A more comprehensive understanding of those microstructural processes and their characterization ...

EPFL2024

Discovery of macrocyclic inhibitors of challenging protein-protein interactions

Edward Jeffrey Will

Macrocycles are a therapeutic modality of interest for drugging challenging disease targets due to their high binding affinity and membrane permeability, enabling the discovery of orally delivered and efficacious therapeutics. Recent methods have enabled t ...

EPFL2024

Ultrasound Imaging: From Physical Modeling to Deep Learning

Dimitris Perdios

Among the medical imaging modalities, ultrasound (US) imaging is one of the safest, most widespread, and least expensive method used in medical diagnosis. In the past decades, several technological advances enabled the advent of ultrafast US imaging, an ac ...

EPFL2021

The genetic architecture of multimodal human brain age

Aleix Boquet I Pujadas

The complex biological mechanisms underlying human brain aging remain incompletely understood. This study investigated the genetic architecture of three brain age gaps (BAG) derived from gray matter volume (GM-BAG), white matter microstructure (WM-BAG), an ...

Nature Portfolio2024

Simultaneous 3D acquisition of H-1 MRF and Na-23 MRI

Tom Hilbert

Purpose To develop a 3D MR technique to simultaneously acquire proton multiparametric maps (T-1, T-2, and proton density) and sodium density weighted images over the whole brain. Methods We implemented a 3D stack-of-stars MR pulse sequence which consists o ...

WILEY2022