Intact Drosophila central nervous system cellular quantitation reveals sexual dimorphism

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Regulation of melanin-based pigmentation is complex, involving multiple genes. Because different genes can contribute to the same pigmentation phenotype, the genes identified in model organisms may not necessarily apply to wild species. In the barn owl (Ty ...

In computational neuroscience, multicompartment models are among the most biophysically realistic representations of single neurons. Constructing such models usually involves the use of the patch-clamp technique to record somatic voltage signals under diff ...

The adaptation of organisms to their environment depends on the innovative potential inherent to genetic variation. In complex organisms such as mammals, processes like development and immunity require tight gene regulation. Complex forms emerge more often ...

This dataset contains some images (TIFF image data) of brain juvenile rats Wistar Han (P14) scanned immunostained slides by using an automated slide scanner (Olympus, VS120-L100, GER) equipped with a UPLSAPO 20x/0.75 air objective (Olympus, GER) and a Pi ...

Since Strahl and Allis proposed the "language of covalent histone modifications", a host of experimental studies have shed light on the different facets of chromatin regulation by epigenetic mechanisms. Initially proposed as a concept for controlling gene ...

AU Lipid: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly transfer proteins (LTPs) are key players in cellular homeostasis : and regulation, as they coordinate the exchange of lipids between different cellular organelles. Despite their importance, ...

Simple Summary The cytoplasm of a living cell is a crowded place, containing hundreds of types of protein and other macromolecules. Cells reliably and continually perform thousands of biochemical reactions to maintain their health. Biomolecular condensates ...

We present the first implementation of the monitoring of airborne fungal spores in real-time using digital holography. To obtain observations of Alternaria spp. spores representative of their airborne stage, we collected events measured in the air during c ...

Background: Transposable elements (TEs) have colonized the genomes of most metazoans, and many TE-embedded sequences function as cis-regulatory elements (CREs) for genes involved in a wide range of biological processes from early embryo- genesis to innate ...

The outstanding information processing capacity of the brain relies on numerous molecular mechanisms. It is an extremely energy-expensive function, which involves specialization and collaboration of different cell types. A common framework to study the com ...

Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis ele ...

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

Essential tremor (ET) is a prevalent movement disorder characterized by marked clinical heterogeneity. Here, we explored the morphometric underpinnings of this cross-subject variability on a cohort of 34 patients with right -dominant drug-resistant ET and ...

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

ABCG2 is an ATP-binding cassette transporter that exports a wide range of xenobiotic compounds and has been recognized as a contributing factor for multidrug resistance in cancer cells. Substrate and inhibitor interactions with ABCG2 have been extensively ...

Intact Drosophila central nervous system cellular quantitation reveals sexual dimorphism

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Melanin and Neurotransmitter Signalling Genes Are Differentially Co-Expressed in Growing Feathers of White and Rufous Barn Owls

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning

Nissl_4, Raw images for Machine learning for histological annotation and quantification of cortical layers

Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

The conformational plasticity of structurally unrelated lipid transport proteins correlates with their mode of action

Macromolecular Crowding Is Surprisingly Unable to Deform the Structure of a Model Biomolecular Condensate

Automatic real-time monitoring of fungal spores: the case of Alternaria spp

Structural and molecular determinants for the interaction of ExbB from Serratia marcescens and HasB, a TonB paralog (vol 5, 355, 2022)

Statistical learning quantifies transposable element-mediated cis-regulation

Molecular reconstruction and simulation of the Neuron-Glia-Vasculature system

Extensive programmed centriole elimination unveiled in C. elegans embryos

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Exploring the heterogeneous morphometric data in essential tremor with probabilistic modelling

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies